TLR3 expression correlates with apoptosis, proliferation and angiogenesis in hepatocellular carcinoma and predicts prognosis

Table 6 Correlation between the expression of TLR3 signaling-pathway proteins and apoptosis-related proteins with apoptosis in HCC tissues

Item	N	TLR3			Spearm		TRIF			Spearman		IRF3			Spearman		NF-κB			Spearman
		expression			analysis		expression			analysis		expression			analysis		expression			analysis
		−	+	++	γ	P	−	+	++	γ	P	−	+	++	γ	P	−	+	++	γ	P
Survinvin					−0.360	0.001				−0.234	0.031				−0.286	0.008				−0.246	0.023
−	44	12	10	22			9	13	22			13	18	13			12	17	15
+	23	12	8	3			10	6	7			15	4	4			9	8	6
++	18	11	4	3			7	6	5			12	2	4			10	6	2
Bcl-2					−0.369	0.001				−0.288	0.008				−0.236	0.030				−0.085	0.438
−	52	16	13	23			14	10	28			21	14	17			17	19	16
+	16	6	5	5			6	5	5			8	5	3			8	6	2
++	17	13	4	0			6	10	1			11	5	1			6	6	5
caspase 3					0.420	0.000				0.225	0.038				0.300	0.005				0.348	0.001
−	24	15	5	4			11	10	3			15	6	3			13	8	3
+	20	10	9	1			3	6	11			13	2	5			9	8	3
++	41	10	8	23			12	9	20			12	16	13			9	15	17
caspase 8					0.310	0.004				0.448	0.000				0.367	0.001				0.279	0.010
−	27	16	4	7			18	3	6			19	4	4			15	7	5
+	23	11	8	4			1	17	5			12	7	4			8	10	5
++	35	8	10	17			7	5	23			9	13	13			8	14	13
caspase 9					0.249	0.022				0.312	0.004				0.275	0.011				0.616	0.000
−	36	19	10	7			15	13	8			24	7	5			27	9	3
+	25	8	8	9			8	4	13			8	7	10			3	21	1
++	24	8	4	12			3	8	13			8	10	6			4	1	19
AI					0.483	0.000				0.566	0.000				0.548	0.000				0.438	0.000
≤10%	33	21	4	8			18	10	5			26	4	3			19	9	5
11% - 20%	37	13	15	9			8	12	17			14	14	9			11	19	7
>20%	15	1	3	11			0	3	12			0	6	9			1	3	11

ISSN: 1471-2407