Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis

BMC Cancer

Table 2 Significantly enriched biological processes affected by cisplatin

Pathway	P-value	Modulated genes in the treated cells	Total genes in the pathway
Expression
Cell cycle	0.001083	85	1399
Enzyme linked receptor protein signaling pathway	0.002002	62	886
Regulation of cell proliferation	0.002877	75	1189
Regulation of cell cycle	0.007228	54	741
Negative regulation of cell cycle	0.02095	39	456
Cell cycle process	0.03652	67	1070
Neurogenesis	0.03869	70	1142
Splicing
mRNA metabolic process	3.89E-12	69	635
RNA splicing	2.102E-10	46	328
mRNA processing	5.512E-10	51	408
RNA processing	1.002E-09	67	671
RNA splicing, via transesterification reactions	7.631E-07	33	219
Nuclear mRNA splicing, via spliceosome	1.935E-05	32	213
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1.935E-05	32	213
Cell cycle	0.01964	89	1455

Genes that were regulated by more than 2-fold (Expression) or transcripts alternatively spliced (Splicing) by cisplatin were analysed by the ToppFun Suite software. The identified biological processes are indicated.

ISSN: 1471-2407