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Table 4 Cost–utility when age limit is raised to 60 and 70 years (representing an annual cohort from England)

From: A model-based assessment of the cost–utility of strategies to identify Lynch syndrome in early-onset colorectal cancer patients

Scenario

Base case (CRC under 50 years)

CRC under 60 years

CRC under 70 years

Incremental costs of Strategy 5 vs Strategy 1(1) [£ Thousands]

Diagnosis

586.0

1590.5

4132.2

CRC prevention

817.1

1630.3

2990.5

CRC treatment

−725.2

−1450.7

−2604.6

EC prevention

374.5

772.5

1430.4

EC treatment

−68.0

−139.2

−247.9

Total

984.5

2403.4

5700.5

Incremental QALYs Strategy 5 vs Strategy 1(1)

Short-term

−4.6

−9.5

−18.1

Long-term

183.9

322.4

574.4

Total

179.3

312.9

556.3

Cost–utility of Strategy 5 vs Strategy 1(1)

ICER [cost per QALY gained]

£5491

£7681

£10247

INHB at WTP £20,000/QALY [QALYs]

130.1

192.8

271.3

  1. Abbreviations: EC endometrial cancer, WTP willingness-to-pay.