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Table 1 Effects of different clinicopathological factors on the survival of patients with combined hepatocellular and cholangiocellular carcinoma after liver transplantation

From: Effect of liver transplantation in combined hepatocellular and cholangiocellular carcinoma: a case series

Prognostic factors Cases (%) Mean survival time (month) P-value
Age    
  <50-year 7 (33%) 50.8 ± 18.1 0.899
  ≥50-year 14 (67%) 45.0 ± 11.8
Preoperative treatment    
  None 13 (62%) 46.7 ± 12.3 0.769
  TACE, RFA, or chemotherapy 8 (38%) 49.0 ± 14.1
Preoperative AFP    
  <20 ng/mL 8 (38%) 44.0 ± 17.2 0.898
  ≥20 ng/mL 13 (62%) 37.1 ± 9.5
Preoperative CA19-9    
  <37U/mL 9 (43%) 53.6 ± 15.8 0.268
  ≥37U/mL 12 (57%) 48.8 ± 8.9
Child-Pugh Grading    
  Grade A 16 (76%) 47.3 ± 13.1 0.347
  Grade B 3 (14%) 39.1 ± 9.1
  Grade C 2 (10%) 53.6 ± 12.0
Cirrhosis*    
  No 3 (14%) 9.0 ± 1.0 0.031
  Yes 18 (86%) 52.8 ± 11.1
Tumor distribution    
  Right lobe 12 (57%) 53.5 ± 12.9 0.265
  Double lobes 9 (43%) 41.3 ± 10.2
Cumulative tumor diameter*    
  ≤5 cm 4 (19%) 83.5 ± 16.9 0.047
  5–10 cm 7 (33%) 32.8 ± 10.1
  >10 cm 10 (48%) 17.7 ± 4.0
Tumor quantity    
  Singular 5 (24%) 37.3 ± 19.2 0.084
  2–3 8 (38%) 50.3 ± 14.8
  ≥4 8 (38%) 34.3 ± 13.0
Lymph node metastasis*    
  Yes 5 (24%) 14.0 ± 6.1 0.039
  No 16 (76%) 54.7 ± 11.7
HCC differentiation    
  Intermediate to well differentiated 16 (76%) 54.3 ± 15.2 0.074
  Poorly differentiated 5 (24%) 45.6 ± 12.1
CC differentiation    
  Intermediate to well differentiated 12 (57%) 56.7 ± 9.3 0.083
  Poorly differentiated 9 (43%) 41.0 ± 13.8
Macroscopic thrombosis*    
  Yes 8 (38%) 21.0 ± 5.1 0.028
  No 13 (62%) 57.9 ± 13.1
Microvascular thrombosis    
  Yes 14 (67%) 42.5 ± 12.5 0.226
  No 7 (33%) 58.8 ± 14.9
Allen typing*    
  Separation/collision 15 (71%) 47.9 ± 9.9 0.037
  Mixed 6 (29%) 21.3 ± 14.2
  1. Note: AFP = alpha-fetoprotein; CA19-9 = carbohydrate antigen 19–9; CC = cholangiocellular carcinoma; HCC = hepatocellular carcinoma; RFA = radio frequency ablation; TACE = transcatheter arterial chemoembolization.
  2. * by the log-rank test, P < 0.05.