Table 2 Distribution of clinical and pathological parameters and levels of miR-200c and miR-141 in blood

Age (years)

0.190

0.240

<55

28

0.35 (0.72)

7.71 (12.47)

≥55

29

1.07 (1.74)

6.4 (15.1)

Menopause

0.572

0.258

Pre-menopausal

24

0.37 (0.68)

7.8 (12.96)

Post-menopausal

33

0.97 (1.68)

6.5 (14.5)

Histology

0.140*

0.712*

Ductal

50

0.69 (1.36)

7.26 (14.22)

Lobular

5

1.3 (1.95)

10.42 (14.67)

Other

2

0.01 (0.01)

0.2 (0.02)

Histological grade

0.106*

0.703*

1

7

1.79 (1.59)

3.84 (4.92)

2

25

0.36 (0.69)

4.19 (7.61)

3

23

0.77 (1.74)

11.72 (19.31)

TNM Stage

0.054

0.001

I-III

44

0.41 (0.83)

8.81 (15.16)

IV

13

1.75 (2.22)

1.06 (3.35)

Lymph nodes involved

0.216

0.014

No

20

1.06 (1.34)

1.53 (3.41)

Yes

37

0.53 (1.38)

10.02 (16.21)

Hormonal receptors

0.460

0.887

Positive

42

0.79 (1.52)

5.03 (9.35)

Negative

14

0.44 (0.86)

13.58 (21.85)

Oestrogen receptors

0.460

0.887

Positive

42

0.79 (1.52)

5.03 (9.35)

Negative

14

0.44 (0.86)

13.58 (21.85)

Progesterone receptors

0.653

0.371

Positive

29

0.59 (1.15)

5.96 (10.53)

Negative

27

0.82 (1.61)

8.46 (16.84)

HER2

0.833

0.037

Positive

14

0.88 (1.41)

1.24 (2.13)

Negative

42

0.64 (1.39)

9.14 (15.5)

MIB1

0.073

0.790

<25%

40

0.90 (1.55)

7.93 (15.24)

>25%

14

0.19 (0.65)

5.99 (10.26)

Type

0.809*

0.105*

Luminal

32

0.71 (1.52)

6.21 (10.4)

HER2

14

0.88 (1.41)

1.24 (2.13)

Triple negative

10

0.41 (0.86)

18.52 (24.35)

Residual disease

0.554

0.755

R0

27

0.52 (0.97)

8.69 (17.24)

R2

30

0.89 (1.66)

5.56 (9.73)

Blood sampling^{^}

0.72

0.128

Before surgery

17

0.24 (0.5)

8.69 (17.24)

After surgery

27

0.52 (0.97)

8.99 (11.59)