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Table 3 Cox proportional hazard model as determined with backward eliminated via a stepwise method *1

From: Homozygous deletions of UGT2B17 modifies effects of smoking on TP53-mutations and relapse of head and neck carcinoma

Outcome: any type ofTP53-mutationsin a tumor

HR

95% CI

p-value

Having both disruptive TP53-mutations and UGT2B17 -deletions

2.22

1.30 to 3.80

0.004

p16 -positive tumor

0.53

0.29 to 0.99

0.047

Stage IV

2.32

1.44 to 3.74

0.001

Poorly differentiated tumor grade

1.66

1.01 to 2.74

0.047

  1. *1By backward elimination from age, gender, smoker (10 PYs ≤), heavy drinker, primary site of tumor, CDKN2A-SCNAs, p16 (+), disruptive TP53-mutations, UGT2B17-deletion, interaction effect between disruptive TP53-mutations and UGT2B17-deletion, interaction between disruptive TP53-mutations and p16 (+), stages, tumor grade of cell differentiation.
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BMC Cancer

ISSN: 1471-2407

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