Figure 1

Kaplan-Meier curves of relapse-free rates in 234 patients with HNSCC. Differences in time until relapse were compared among combinations of p16 (+) tumors, disruptive TP53-mutations, and homozygous UGT2B17 deletions. The group of both UGT2B17-deletion and a disruptive TP53-mutation in the primary tumors is indicated as green-colored line, the group of both p16 (+) and no disruptive TP53-mutation in the primary tumors is indicated as blue-colored line and the other groups are indicated as red-colored line. p16 (+): p16-positive tumor; p16 (-): p16- negative tumor; dTP53 (+): presence of disruptive TP53-mutations; dTP53 (-): no disruptive TP53-mutations or wild-type TP53; UGT2B17 (+): UGT2B17-deletion: homozygous deletion of UGT2B17; UGT2B17 (-): UGT2B17-presence: one or two copies of UGT2B17.