Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma

BMC Cancer

Table 3 Univariate and multivariate analyses of CA7 expression and disease-specific survival of patients in the training and validation cohorts

Variables	Categories	Univariate analysis			Multivariate analysis^b
		HR	95% CI	P value^c	HR	95% CI	P value^c
Training Cohort
Age (years)	≥60 / <60	2.263	1.389-3.687	0.001	2.770	1.691-4.537	<0.001
Sex	Male / female	0.878	0.596-1.293	0.510
Tumor location	Colon / rectum	1.401	0.923-2.125	0.113
Tumor size (cm)	≥5 / <5	1.114	0.753-1.648	0.590
Differentiation grade	Poor / well + moderate	2.626	1.761-3.916	<0.001	2.010	1.337-3.023	0.001
TNM stage	III / I+ II	2.734	1.846-4.048	<0.001	2.402	1.603-3.598	<0.001
CA7 expression^a	Low / high	2.469	1.642-3.717	<0.001	2.247	1.481-3.401	<0.001
Validation Cohort
Age (years)	≥60 / <60	1.976	1.080-3.614	0.027	2.293	1.247-4.217	0.008
Sex	Male / female	0.737	0.459-1.183	0.207
Tumor location	Colon / rectum	0.961	0.599-1.542	0.868
Tumor size (cm)	≥5 / <5	0.814	0.503-1.317	0.403
Differentiation grade	Poor / well + moderate	1.688	1.017-2.803	0.043
TNM stage	III / I+ II	2.828	1.734-4.611	<0.001	2.674	1.615-4.428	<0.001
CA7 expression^a	Low / high	2.632	1.520-4.545	0.001	2.058	1.174-3.610	0.012

Abbreviations: HR hazard ratio, 95% CI 95% confidence interval.
^aFor CA7, median values were used as the cut-off point for definition of subgroups (low expression and high expression groups).
^bMultivariate models were adjusted for age, sex, tumor location, tumor size, differentiation grade, and TNM stage.
^cBold type indicates statistical significance.

ISSN: 1471-2407