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Table 3 Univariate and multivariate analyses of CA7 expression and disease-specific survival of patients in the training and validation cohorts

From: Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma

Variables Categories Univariate analysis Multivariate analysisb
   HR 95% CI P valuec HR 95% CI P valuec
Training Cohort
Age (years) ≥60 / <60 2.263 1.389-3.687 0.001 2.770 1.691-4.537 <0.001
Sex Male / female 0.878 0.596-1.293 0.510    
Tumor location Colon / rectum 1.401 0.923-2.125 0.113    
Tumor size (cm) ≥5 / <5 1.114 0.753-1.648 0.590    
Differentiation grade Poor / well + moderate 2.626 1.761-3.916 <0.001 2.010 1.337-3.023 0.001
TNM stage III / I+ II 2.734 1.846-4.048 <0.001 2.402 1.603-3.598 <0.001
CA7 expressiona Low / high 2.469 1.642-3.717 <0.001 2.247 1.481-3.401 <0.001
Validation Cohort
Age (years) ≥60 / <60 1.976 1.080-3.614 0.027 2.293 1.247-4.217 0.008
Sex Male / female 0.737 0.459-1.183 0.207    
Tumor location Colon / rectum 0.961 0.599-1.542 0.868    
Tumor size (cm) ≥5 / <5 0.814 0.503-1.317 0.403    
Differentiation grade Poor / well + moderate 1.688 1.017-2.803 0.043    
TNM stage III / I+ II 2.828 1.734-4.611 <0.001 2.674 1.615-4.428 <0.001
CA7 expressiona Low / high 2.632 1.520-4.545 0.001 2.058 1.174-3.610 0.012
  1. Abbreviations: HR hazard ratio, 95% CI 95% confidence interval.
  2. aFor CA7, median values were used as the cut-off point for definition of subgroups (low expression and high expression groups).
  3. bMultivariate models were adjusted for age, sex, tumor location, tumor size, differentiation grade, and TNM stage.
  4. cBold type indicates statistical significance.