MTUS1/ATIP3a knockdown promotes the migration and invasion of SACC. (A) Obviously reductions in ATIP3a protein levels were observed in the ATIP3a siRNA-transfected SACC-83 cells compared to the negative control-siRNA transfected cells. SACC-83 cells displayed increased Slug, Vimentin and pERK1/2 protein levels and decreased E-cadherin protein levels upon ATIP3a knockdown. (B, C) ATIP3a knockdown promotes the migration and invasion of SACC-83 cells. (D) The cell proliferation rate of the SACC-83 cells was significantly promoted after transfection with the ATIP3a siRNA. *: P <0.05.