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Table 1 Baseline characteristics of 90 patients with TNBC by NLR

From: Pre-treatment neutrophil to lymphocyte ratio may be a useful tool in predicting survival in early triple negative breast cancer patients

Characteristics Total (n = 90) NLR ≤3 (n = 73) NLR > 3 (n = 17) p-value
Age     
  ≤50 years 41 (45.5) 35 (38.8) 6 (6.7) 0.17
  >50 years 49 (54.5) 38 (42.3) 11 (12.2)
Performance status     
  ECOG 0 70 (77.7) 62 (68,8) 8 (8.9) 0.37
  ECOG 1 20 (22.3) 11 (12.3) 9 (10.0)
Menopausal status     
  Pre- 36 (40.0) 31 (34.4) 5 (5.6) 0.44
  Post- 54 (60.0) 42 (46.7) 12 (13.3)
Tumour size     
  pT1 52 (57.7) 45 (49.9) 7 (7.8) 0.56
  pT2 37 (41.1) 27 (30.0) 10 (11.1)
  pT3 1 (1.2) 1 (1.2) 0 (0)
Lymph node status (pN)     
  pN0 52 (57.7) 42 (46.6) 10 (11.1) 0.44
  pN1 28 (31.2) 24 (26.7) 4 (4.5)
  pN2 10 (11.1) 7 (7.8) 3 (3,3)
Stage*     
  I 33 (36.7) 29 (32.2) 4 (4.5) 0.39
  II 48 (53.3) 38 (42.2) 10 (11.1)
  IIIA 9 (10.0) 6 (6.7) 3 (3.3)
Tumour histology     
  Ductal carcinoma 82 (91.1) 69 (76.7) 13 (14.4) 0.29
  Lobular carcinoma 1 (1.2) 0 (0) 1 (1.2)
  Other 7 (7.7) 4 (4.4) 3 (3.3)
Histologic grade     
  I-II 9 (10.0) 7 (7.8) 2 (2.2) 0.84
  III 81 (90.0) 66 (73.3) 15 (16.7)
Ki-67     
  ≤20% 15 (16.6) 13 (14.4) 2 (2.2) 0.79
  >20% 75 (83.4) 60 (66.7) 15 (16.7)
Lympho-vascular invasion     
  Yes 14 (15.6) 7 (7.8) 7 (7.8) 0.07
  No 76 (84.4) 66 (73.3) 10 (11.1)
Necrosis     
  Yes 15 (16.6) 11 (12.1) 4 (4.5) 0.89
  No 75 (83.4) 62 (69.0) 13 (14.4)
Type of surgery     
  Quadrantectomy 71 (77.9) 60 (65.7) 11 (12.2) 0.75
  Radical mastectomy 19 (22.1) 13 (15.4) 6 (6.7)
Adjuvant chemotherapy     
  Antracycline containing 48 (53.3) 40 (44.4) 8 (8.9) 0.59
  CMF 40 (44.5) 31 (34.5) 9 (10.0)
  No 2 (2.2) 2 (2.2) 0 (0)
Adjuvant radiotherapy     
  Yes 71 (77.9) 60 (65.7) 11 (12.2) 0.61
  No 19 (22.1) 13 (15.4) 6 (6.7)
Recurrences     
  Yes 13 (14.5) 8 (8.9) 5 (5.6) 0.12
  No 77 (85.5) 65 (72.2) 12 (13.3)
Deaths     
  Yes 8 (8.9) 4 (4.4) 4 (4.5) 0.06
  No 82 (91.1) 69 (76.7) 13 (14.4)
  1. Table 1 shows the lack of significant correlation among pre-treatment NLR and clinical pathological factors.
  2. *AJCC. Cancer Staging manual. Seventh edition. New York, Springer 2009.
  3. Legend: NLR = Neutrophil to Lymphocyte Ratio; TNBC = Triple Negative Breast Cancer.