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Table 3 Multivariate logistic regression model for pathological complete response

From: Association between CHEK2 H371Y mutation and response to neoadjuvant chemotherapy in women with breast cancer

Variable Pathological complete response (pCR) P-value
   OR (95% CI)  
CHEK2 H371Y (MT v WT) 3.01 (1.34-6.78) 0.008
Age (≤50 v >50 years) 1.26 (0.99-1.61) 0.06
Tumor grade (III v I + II) 2.28 (1.71-3.03) <0.001
Tumor size (<2 v ≥2 cm) 1.76 (1.38-2.24) <0.001
Lymph nodes (Negative v Positive) 2.10 (1.63-2.71) <0.001
ER (Negative v Positive) 1.99 (1.48-2.67) <0.001
PgR (Negative v Positive) 1.65 (1.21-2.26) 0.002
HER2 (Positive v Negative) 1.36 (1.05-1.75) 0.021
Trastuzumab use (Yes v No) 2.42 (1.47-3.99) 0.001
  1. ER, Estrogen receptor; PgR, Progesterone receptor; HER2, human epidermal growth factor receptor.