The role of androgen deprivation therapy on biochemical failure and distant metastasis in intermediate-risk prostate cancer: effects of radiation dose escalation

Table 4 Cox models for biochemical failure and distant metastasis

	Biochemical failure						Distant metastasis
	Initial cox			Matched cox analysis			Initial cox
Variable	Hazard	95% CI	p-value	Hazard	95% CI	p-value	Hazard	95% CI	p-value
	Ratio			Ratio
Age	1.003	0.983-1.024	0.76	0.983	0.955-1.011	0.235	1.022	0.972-1.074	0.393
Pre-treatment PSA	1.079	1.042-1.111	<0.001	1.055	0.997-1.116	0.062	1.077	1.004-1.155	0.039
Gleason Score	1.118	1.021-1.393	0.026	1.996	1.045-3.812	0.036	1.480	1.020-2.149	0.039
Year of diagnosis	0.923	0.875-9.74	0.004	0.992	0.907-1.085	0.867	0.969	0.856-1.098	0.623
T-stage	1.164	0.987-1.373	0.072	1.371	1.058-1.774	0.017	1.820	1.201-2.759	0.005
Radiation dose (high vs low)	0.864	0.572-1.306	0.489	0.928	0.490-1.757	0.818	1.039	0.413-2.609	0.936
Adjuvant Hormone use (yes vs no)	0.599	0.364-0.978	0.04	0.487	0.288-0.822	0.007	0.114	0.014-0.905	0.04
Interaction term ADT x XRT	3.883	0.873-17.26	0.075

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