Table 2 Dose modification of Irinotecan and 5-fluorouracil (5-FU) (N = 89)
Dose Level | Dose (mg/m2) | N | % | Duration until modification (days) | ||
|---|---|---|---|---|---|---|
Median | Range | |||||
Irinotecan | 0 | 180 | 52 | 58.4 | - | - |
−1 | 150 | 37 | 41.6 | 33.0 | (14–448) | |
−2 | 125 | 12 | 13.5 | 76.5 | (14–146) | |
−3 | 100 | 3 | 3.4 | 112.0 | (47–181) | |
5-FU (bolus/infusion)* | 0 | 400/2,400 | 55 | 61.8 | - | - |
−1 | 400/2,000 | 34 | 38.2 | 47.5 | (14–448) | |
−2 | 0/1,600 | 9 | 10.1 | 82.0 | (33–301) | |