|
Drugs
|
Mean Tumor Volume
|
Growth inhibition (TGI%)
|
P value vs PBS
|
P value vs Bevacizumab
|
|---|
|
HB-002.1, 5 mg/kg
|
2.72 (2.51-2.91)
|
78.02
|
<0.0001
|
<0.0001
|
|
HB-002.1, 20 mg/kg
|
1.89 (1.66-2.16)
|
84.71
|
<0.0001
|
<0.0001
|
|
Bevacizumab, 5 mg/kg
|
4.40 (3.59-5.40)
|
64.46
|
<0.0001
|
NA
|
|
Bevacizumab, 20 mg/kg
|
4.02 (3.36-4.81)
|
67.55
|
<0.0001
|
NA
|
|
PBS
|
12.38 (9.87-15.54)
|
0.00
|
NA
|
NA
|
- Sample size = 10 for each group.
- Mean Tumor Volume = geometric mean with 95% confidence interval in parentheses. Geometric mean is shown because statistical analyses utilized log-transformed data that best modeled tumor volume growth.
- P value was calculated as described in Methods.
- P value vs Bevacizumab is compared to same dose of HB-002.1.
- NA = not applicable.
