Figure 1From: Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinaseCytotoxicity of cyproheptadine toward normal human hepatocytes (HH) and HCC cell lines HepG2 and Huh-7. Cells in 96-well plates were cultured for 24 h, starved in serum-free medium for 24 h, and then treated with various concentrations of cyproheptadine for 24 h. Viability was determined for the treated cells using Cell Counting Kit-8. Data are presented as mean ± SD (n = 6). Significant differences from the no-treatment control, determined by one-way ANOVA and Dunnett’s comparison test, are indicated by asterisks: *p < 0.05; ***p < 0.001.Back to article page