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Table 4 Percentage distribution of VEGFR-1 and pVEGFR-1 in tumor cells of CC tissue

From: Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis

  Score N0/M0 (%) N+ (%) N0/M0 vs. N + p M+ (%) N0/M0 vs. M + p CC (%)
Tumor center
VEGFR-1 0 3 21 0.03 16 NS 0.1 13
1 11 21 12 87
2 86 58 72
pVEGFR-1 Tyr1048 0 11 29 NS 0.09 30 0.01 26
74
1 59 54 44
2 30 17 16
pVEGFR-1 Tyr1213 0 19 38 NS 0.1 52 0.01 36
64
1 64 46   32
2 17 16   16
pVEGFR-1 Tyr1333 0 38 46 NS 0.8 52 NS 0.3 45
55
1 49 33 44
2 13 21 4
Tumor budding
VEGFR-1 0 0 5 NS 0.4 12 NS 0.1 6
94
1 15 15 12
2 85 80 76
pVEGFR-1 Tyr1048 0 4 30 0.01 40 0.003 29
71
1 66 50 44
2 30 20 16
pVEGFR-1 Tyr1213 0 19 38 NS 0.2 52 0.01 36
64
1 64 46 32
2 17 16 16
pVEGFR-1 Tyr1333 0 46 50 NS 1.0 64 NS 0.3 53
47
1 43 25 32
2 11 25 4
  1. The intensity of the tumoral staining was scored on a semiquantitative scale from 0 to 2 for the investigated biomolecule (0: no staining, 1: weak staining, 2: strong staining). For the statistical analysis using Fisher´s exact test the examined cases were separated into two groups characterized by a negative/positive expression. The line in the staining intensity column indicates this dichotomization for each biomolecule. The line in the column “CC %” indicates the percentage distribution of colon carcinomas with negative and positive expression of each biomolecule. p < 0.05 was taken as statistically significant. NS, not significant.