Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis

BMC Cancer

Table 4 Percentage distribution of VEGFR-1 and pVEGFR-1 in tumor cells of CC tissue

	Score	N0/M0 (%)	N+ (%)	N0/M0 vs. N + p	M+ (%)	N0/M0 vs. M + p	CC (%)
Tumor center
VEGFR-1	0	3	21	0.03	16	NS 0.1	13
	1	11	21		12		87
	2	86	58		72		87
pVEGFR-1 ^Tyr1048	0	11	29	NS 0.09	30	0.01	26
	0	11	29		30		74
	1	59	54		44
	2	30	17		16
pVEGFR-1 ^Tyr1213	0	19	38	NS 0.1	52	0.01	36
	0	19	38	NS 0.1	52		64
	1	64	46		32
	2	17	16		16
pVEGFR-1 ^Tyr1333	0	38	46	NS 0.8	52	NS 0.3	45
	0	38	46		52		55
	1	49	33		44
	2	13	21		4
Tumor budding
VEGFR-1	0	0	5	NS 0.4	12	NS 0.1	6
	0	0	5		12		94
	1	15	15		12
	2	85	80		76
pVEGFR-1 ^Tyr1048	0	4	30	0.01	40	0.003	29
	0	4	30		40		71
	1	66	50		44
	2	30	20		16
pVEGFR-1 ^Tyr1213	0	19	38	NS 0.2	52	0.01	36
	0	19	38		52		64
	1	64	46		32
	2	17	16		16
pVEGFR-1 ^Tyr1333	0	46	50	NS 1.0	64	NS 0.3	53
	0	46	50		64		47
	1	43	25		32
	2	11	25		4

The intensity of the tumoral staining was scored on a semiquantitative scale from 0 to 2 for the investigated biomolecule (0: no staining, 1: weak staining, 2: strong staining). For the statistical analysis using Fisher´s exact test the examined cases were separated into two groups characterized by a negative/positive expression. The line in the staining intensity column indicates this dichotomization for each biomolecule. The line in the column “CC %” indicates the percentage distribution of colon carcinomas with negative and positive expression of each biomolecule. p < 0.05 was taken as statistically significant. NS, not significant.

ISSN: 1471-2407