Figure 6

Chromosomal instability and outlier scores in CUP. Panel A. Two-way hierachial cluster of the Ferreira_Ewing_Sarcoma_Unstable signature in MOKO and CUPs. MOKO and CUPs are indicated by green and pink labels, respectively. Panel B. Instability scores in Normal tissues, Primary tumors, MOKO and CUPs. The signature of chromosome unstable sarcoma was employed to generate an instability score calculated as the mean of the expression values from the included probe sets of the signature following variance filtering (206 probe sets). Panel C. Linear correlation between outlier scores and instability scores. Primary tumors, metastasis of known origin and CUP are indicated as black, red or green dots, respectively. The lower panel shows the value of the instability scores depicted in a green to red color scale. The p-value of the linear correlation between outlier and instability scores is indicated.