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Table 2 Associations between cytokines and colorectal adenomas among participants in the IRAS Colon Study

From: Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma

Cytokines

Adenoma prevalence n/N (%)

Crude OR (95% CI)

Adjusted OR (95% CI)

GM-CSF

   

L

67/124 (54.0)

1.00

1.00

M

17/37 (46.0)

0.72 (0.35 1.51)

0.83 (0.38 1.82)

H

13/33 (39.4)

0.55 (0.25 1.21)

0.70 (0.30 1.62)

p for trend

  

0.38

Interferon gamma

   

L

37/77 (48.1)

1.00

1.00

M

42/71 (59.2)

1.57 (0.82 3.00)

1.35 (0.67 2.72)

H

18/46 (39.1)

0.69 (0.33 1.46)

0.77 (0.35 1.69)

p for trend

  

0.67

IL-10

   

L

55/112 (49.1)

1.00

1.00

M

18/38 (47.4)

0.93 (0.45 1.95)

0.91 (0.41 2.00)

H

24/44 (54.6)

1.24 (0.62 2.50)

1.45 (0.69 3.08)

p for trend

  

0.40

IL-12p70

   

L

50/103 (48.5)

1.00

1.00

M

35/57 (61.4)

1.69 (0.87 3.26)

1.86 (0.92 3.76)

H

12/34 (35.3)

0.58 (0.26 1.29)

0.59 (0.25 1.42)

p for trend

  

0.68

IL-17A

   

L

82/152 (54.0)

1.00

1.00

M

5/19 (26.3)

0.30 (0.10 0.89)

0.42 (0.14 1.30)

H

10.23 (43.5)

0.66 (0.27 1.59)

0.83 (0.33 2.13)

p for trend

  

0.40

IL-18

   

L

67/127 (52.8)

1.00

1.00

M

12/31 (38.7)

0.57 (0.25 1.26)

0.81 (0.34 1.96)

H

18/36 (50.0)

0.90 (0.43 1.88)

1.09 (0.50 2.41)

p for trend

  

0.93

IL-2

   

L

37/132 (50.8)

1.00

1.00

M

15/31 (48.4)

0.91 (0.42 1.99)

1.25 (0.53 2.96)

H

15/31 (48.4)

0.91 (0.42 1.99)

1.14 (0.49 2.62)

p for trend

  

0.67

IL-4

   

L

56/117 (47.9)

1.00

1.00

M

24/42 (57.1)

1.45 (0.71 2.96)

1.83 (0.84 3.98)

H

17/35 (48.6)

1.03 (0.48 2.19)

1.33 (0.59 3.02)

p for trend

  

0.29

IL-6

   

L

53/117 (45.3)

1.00

1.00

M

29/46 (63.0)

2.06 (1.02 4.15)

2.57 (1.19 5.54)

H

15/31 (48.4)

1.13 (0.51 2.50)

1.35 (0.58 3.19)

p for trend

  

0.17

IL-7

   

L

40/73 (54.8)

1.00

1.00

M

28/60 (46.7)

0.72 (0.36-1.43)

0.59 (0.28-1.24)

H

29/61 (47.5)

0.75 (0.38-1.48)

0.60

p for trend

   

MIP-1β

   

L

22/53 (41.5

1.00

1.00

M

53/87 (60.9)

2.20 (1.10-4.40

2.69 (1.25-5.80)

H

22/54 (4.7)

0.97 (0.45-2.09)

1.25 (0.54-2.91)

p for trend

  

0.65

RANTES

   

L

46/79 (58.2)

1.00

1.00

M

32/64 (50.0)

0.72 (0.37-1.39)

0.66 (0.33-1.35)

H

19/51 (37.3)

0.43 (0.21-0.88)

0.46 (0.21-0.99)

p for trend

  

0.04

VEGF

   

L

13/19 (68.4)

1.00

1.00

M

40/86 (46.5)

0.40 (0.14-1.15)

0.42 (0.14-1.28)

H

44/89 (49.4)

0.45 (0.46-1.29)

0.62 (0.20-1.88)

p for trend

  

0.97

TNFα

   

L

31/64 (48.9)

1.00

1.00

M

37/68 (54.4)

1.27 (0.64-2.51)

1.27 (0.64-2.52)

H

29/62 (46.8)

0.93 (0.46-1.88)

1.14 (0.55-2.35)

p for trend

  

0.54

  1. Tertiles were generated with those undetectable as the referent value and then the other tertiles based on the median of cytokines values from participants with normal colonoscopies except for those in bold. Those in bold had no or only a few undetectable values so tertiles were based on the distribution in normal point. Multivariate unconditional logistic regression was used to evaluate the association between adenoma prevalence and the categories of each cytokine individually while controlling for potential confounders. Low (denoted by L), medium (denoted by M), and high (denoted by H) cytokine concentrations are indicated. Statistically significant results indicated in bold type.
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BMC Cancer

ISSN: 1471-2407

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