| | |
NAT1 rapid acetylators
| |
NAT1 slow/intermediate acetylators
|
---|
Population
|
Risk factors
|
Variables
|
Controls
|
Cases
|
OR (95% CI)a
|
P-value
|
Controls
|
Cases
|
OR (95% CI)a
|
P-value
|
---|
Black
| | | | | | | | | | |
|
Tobacco smoking
|
Never smokers
|
84
|
61
|
1 (Ref)
| |
166
|
109
|
1 (Ref)
| |
| |
Smokersb
|
71
|
81
|
1.71 (0.73-4.04)
|
0.218
|
142
|
186
|
3.41 (1.95-5.96)
|
<0.0001
|
|
Tot cigarettes/day
|
0
|
84
|
61
|
1 (Ref)
| |
166
|
109
|
1 (Ref)
| |
| |
≤9
|
45
|
50
|
1.80 (0.72-4.53)
|
0.208
|
87
|
123
|
3.96 (2.19-7.13)
|
<0.0001
|
| |
≥10
|
24
|
31
|
2.06 (0.73-5.84)
|
0.174
|
45
|
57
|
2.97 (1.47-5.99)
|
0.002
|
|
Alcohol drinking
|
Non-drinkers
|
66
|
53
|
1 (Ref)
| |
130
|
112
|
1 (Ref)
| |
| |
Drinkersc
|
89
|
89
|
1.17 (0.52-2.59)
|
0.707
|
177
|
182
|
0.87 (0.54-1.40)
|
0.570
|
Red meat intake d
|
3 times/week or less
|
−
|
81
| | |
−
|
168
|
1 (Ref)
| | |
| |
Daily or almost daily
|
−
|
12
| | |
−
|
23
|
0.93 (0.43-2.0)
|
0.851
|
|
White meat intaked
|
3 times/week or less
|
−
|
56
| | |
−
|
87
|
1 (Ref)
| |
| |
Daily or almost daily
|
−
|
38
| | |
−
|
104
|
1.82 (1.09-3.04)
|
0.023
|
Mixed Ancestry
| | | | | | | | | | |
|
Tobacco smoking
|
Never smokers
|
17
|
1
|
1 (Ref)
| |
43
|
14
|
1 (Ref)
| |
| |
Smokersb
|
33
|
46
|
−
|
−
|
191
|
194
|
−
|
−
|
|
Tot cigarettes/day
|
0
|
17
|
1
|
1 (Ref)
| |
43
|
14
|
1 (Ref)
| |
| |
≤9
|
17
|
24
|
−
|
−
|
101
|
58
|
−
|
−
|
| |
≥10
|
11
|
20
|
−
|
−
|
77
|
133
|
−
|
−
|
|
Alcohol drinking
|
Non-drinkers
|
21
|
12
|
1 (Ref)
| |
93
|
39
|
1 (Ref)
| |
| |
Drinkersc
|
29
|
35
|
0.80 (0.19-3.44)
|
0.764
|
140
|
170
|
3.41 (1.70-6.81)
|
0.001
|
|
Red meat intaked
|
3 times/week or less
|
−
|
22
| | |
−
|
81
|
1 (Ref)
| |
| |
Daily or almost daily
|
−
|
7
| | |
−
|
42
|
1.32 (0.49-3.55)
|
0.586
|
|
White meat intaked
|
3 times/week or less
|
−
|
16
| | |
−
|
56
|
1 (Ref)
| |
| |
Daily or almost daily
|
−
|
13
| | |
−
|
66
|
1.58 (0.68-3.67)
|
0.288
|
- Samples with unknown acetylator status are not shown.
- Ref = reference allele.
- aOR was adjusted for age, gender, smoking and alcohol consumption status; OR was not calculated for subgroups with low sample size.
- bSmokers = current and former smokers.
- cDrinkers = light to heavy alcohol drinkers.
- dCase-only analysis has been performed for red meat intake due to lack of data from control individuals.