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Table 3 Distribution of NAT1 and NAT2 acetylation polymorphisms and association with OSCC in the Black and Mixed Ancestry populations

From: NAT1 and NAT2 genetic polymorphisms and environmental exposure as risk factors for oesophageal squamous cell carcinoma: a case-control study

   Black Mixed Ancestry
Gene Acetylator status Controls (%) Cases (%) OR (95% CI)a P-value Controls (%) Cases (%) OR (95% CI)a P-value
NAT2 Rapid 87 (18) 90 (19) 1 (Ref)   49 (17) 57 (21) 1 (Ref)  
Intermediate 231 (48) 192 (41) 0.77 (0.50-1.20) 0.248 124 (43) 113 (42) 0.47 (0.28-0.80) 0.004
Slow 155 (32) 161 (35) 0.88 (0.56-1.39) 0.588 115 (40) 91 (34) 0.40 (0.24-0.68) 0.001
Unknown 7 (1) 20 (4)    0 (0) 8 (3)   
Slow + intermediate 386 (82) 353 (79) 0.82 (0.54-1.23) 0.333 239 (83) 204 (78) 0.44 (0.27-0.70) 0.001
NAT1 Rapid 155 (32) 142 (31) 1 (Ref)   50 (17) 47 (17) 1 (Ref)  
Intermediate 219 (46) 196 (42) 0.72 (0.49-1.05) 0.084 128 (44) 130 (48) 1.04 (0.50-2.17) 0.908
Slow 89 (18) 100 (22) 0.94 (0.59-1.48) 0.781 106 (37) 81 (30) 0.64 (0.29-1.37) 0.249
Unknown 17 (3) 25 (5)    4 (1) 11 (4)   
Slow + intermediate 308 (66) 296 (68) 0.78 (0.55-1.11) 0.166 234 (82) 211 (81) 0.85 (0.43-1.68) 0.638
  1. aOdds ratio was adjusted for age, gender, tobacco smoking, and alcohol consumption status.
  2. Ref = reference allele.
  3. NAT2 rapid = NAT2*4/*4.
  4. NAT2 intermediate = NAT2*4/*5, NAT2*4/*6, NAT2*4/*7, or NAT2*4/*14.
  5. NAT2 slow = any combination of NAT2*5, NAT2*6, NAT2*7, and NAT2*14.
  6. NAT1 rapid = NAT1*10/*10.
  7. NAT1 intermediate = NAT1*10/*4 or NAT1*10/*3.
  8. NAT1 slow = NAT1*4/*4, NAT1*4/*3, or NAT1*3/*3.
  9. *Indicates the allele for each of the genes.
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