|  | Black | Mixed Ancestry | ||||||
---|---|---|---|---|---|---|---|---|---|
Gene | Acetylator status | Controls (%) | Cases (%) | OR (95% CI)a | P-value | Controls (%) | Cases (%) | OR (95% CI)a | P-value |
NAT2 | Rapid | 87 (18) | 90 (19) | 1 (Ref) | Â | 49 (17) | 57 (21) | 1 (Ref) | Â |
Intermediate | 231 (48) | 192 (41) | 0.77 (0.50-1.20) | 0.248 | 124 (43) | 113 (42) | 0.47 (0.28-0.80) | 0.004 | |
Slow | 155 (32) | 161 (35) | 0.88 (0.56-1.39) | 0.588 | 115 (40) | 91 (34) | 0.40 (0.24-0.68) | 0.001 | |
Unknown | 7 (1) | 20 (4) | Â | Â | 0 (0) | 8 (3) | Â | Â | |
Slow + intermediate | 386 (82) | 353 (79) | 0.82 (0.54-1.23) | 0.333 | 239 (83) | 204 (78) | 0.44 (0.27-0.70) | 0.001 | |
NAT1 | Rapid | 155 (32) | 142 (31) | 1 (Ref) | Â | 50 (17) | 47 (17) | 1 (Ref) | Â |
Intermediate | 219 (46) | 196 (42) | 0.72 (0.49-1.05) | 0.084 | 128 (44) | 130 (48) | 1.04 (0.50-2.17) | 0.908 | |
Slow | 89 (18) | 100 (22) | 0.94 (0.59-1.48) | 0.781 | 106 (37) | 81 (30) | 0.64 (0.29-1.37) | 0.249 | |
Unknown | 17 (3) | 25 (5) | Â | Â | 4 (1) | 11 (4) | Â | Â | |
Slow + intermediate | 308 (66) | 296 (68) | 0.78 (0.55-1.11) | 0.166 | 234 (82) | 211 (81) | 0.85 (0.43-1.68) | 0.638 |