| | |
Black
|
Mixed Ancestry
|
|---|
|
Gene
|
Acetylator status
|
Controls (%)
|
Cases (%)
|
OR (95% CI)a
|
P-value
|
Controls (%)
|
Cases (%)
|
OR (95% CI)a
|
P-value
|
|---|
|
NAT2
|
Rapid
|
87 (18)
|
90 (19)
|
1 (Ref)
| |
49 (17)
|
57 (21)
|
1 (Ref)
| |
|
Intermediate
|
231 (48)
|
192 (41)
|
0.77 (0.50-1.20)
|
0.248
|
124 (43)
|
113 (42)
|
0.47 (0.28-0.80)
|
0.004
|
|
Slow
|
155 (32)
|
161 (35)
|
0.88 (0.56-1.39)
|
0.588
|
115 (40)
|
91 (34)
|
0.40 (0.24-0.68)
|
0.001
|
|
Unknown
|
7 (1)
|
20 (4)
| | |
0 (0)
|
8 (3)
| | |
|
Slow + intermediate
|
386 (82)
|
353 (79)
|
0.82 (0.54-1.23)
|
0.333
|
239 (83)
|
204 (78)
|
0.44 (0.27-0.70)
|
0.001
|
|
NAT1
|
Rapid
|
155 (32)
|
142 (31)
|
1 (Ref)
| |
50 (17)
|
47 (17)
|
1 (Ref)
| |
|
Intermediate
|
219 (46)
|
196 (42)
|
0.72 (0.49-1.05)
|
0.084
|
128 (44)
|
130 (48)
|
1.04 (0.50-2.17)
|
0.908
|
|
Slow
|
89 (18)
|
100 (22)
|
0.94 (0.59-1.48)
|
0.781
|
106 (37)
|
81 (30)
|
0.64 (0.29-1.37)
|
0.249
|
|
Unknown
|
17 (3)
|
25 (5)
| | |
4 (1)
|
11 (4)
| | |
|
Slow + intermediate
|
308 (66)
|
296 (68)
|
0.78 (0.55-1.11)
|
0.166
|
234 (82)
|
211 (81)
|
0.85 (0.43-1.68)
|
0.638
|
- aOdds ratio was adjusted for age, gender, tobacco smoking, and alcohol consumption status.
- Ref = reference allele.
- NAT2 rapid = NAT2*4/*4.
- NAT2 intermediate = NAT2*4/*5, NAT2*4/*6, NAT2*4/*7, or NAT2*4/*14.
- NAT2 slow = any combination of NAT2*5, NAT2*6, NAT2*7, and NAT2*14.
- NAT1 rapid = NAT1*10/*10.
- NAT1 intermediate = NAT1*10/*4 or NAT1*10/*3.
- NAT1 slow = NAT1*4/*4, NAT1*4/*3, or NAT1*3/*3.
- *Indicates the allele for each of the genes.
