| | | |
Black
|
Mixed Ancestry
|
|---|
|
Gene
|
SNP
|
Polymorphism
|
Controls (%)
|
Cases (%)
|
OR (95% CI)a
|
P-value
|
Controls (%)
|
Cases (%)
|
OR (95% CI)a
|
P-value
|
|---|
|
NAT2
|
590G>A
|
G / G
|
296 (62.3)
|
257 (57.2)
|
1 (Ref)
|
-
|
172 (59.7)
|
159 (60.0)
|
1 (Ref)
|
-
|
|
(NAT2*6)
|
G / A
|
155 (32.6)
|
163 (36.3)
|
1.20 (0.85 - 1.69)
|
0.299
|
105 (36.4)
|
93 (35.1)
|
0.69 (0.39 - 1.21)
|
0.192
|
|
rs1799930
|
A / A
|
24 (5.0)
|
29 (6.4)
|
1.46 (0.72 - 2.94)
|
0.291
|
11 (3.8)
|
13 (4.9)
|
1.30 (0.34 - 4.91)
|
0.697
|
|
341T>C
|
T / T
|
247 (52.1)
|
237 (53.0)
|
1 (Ref)
|
-
|
130 (45.1)
|
147 (55.7)
|
1 (Ref)
|
-
|
|
(NAT2*5)
|
T / C
|
179 (37.8)
|
178 (39.8)
|
0.97 (0.69 - 1.36)
|
0.856
|
125 (43.4)
|
101 (38.2)
|
0.59 (0.34 - 1.04)
|
0.069
|
|
rs1801280
|
C / C
|
48 (10.1)
|
32 (7.1)
|
0.55 (0.30 - 0.99)
|
0.05
|
33 (11.5)
|
16 (6.1)
|
0.31 (0.11 - 0.87)
|
0.026
|
|
857G>A
|
G / G
|
471 (98.9)
|
440 (98.2)
|
1 (Ref)
|
-
|
265 (92.0)
|
237 (90.5)
|
1 (Ref)
|
-
|
|
(NAT2*7)
|
G / A
|
5 (1.0)
|
7 (1.6)
|
0.95 (0.19 - 4.77)
|
0.948
|
23 (8.0)
|
24 (9.2)
|
1.32 (0.54 - 3.23)
|
0.548
|
|
rs1799931
|
A / A
|
0 (0)
|
1 (0.2)
|
−
| |
0 (0)
|
1 (0.4)
|
−
| |
|
191G>A
|
G / G
|
417 (87.6)
|
402 (90.1)
|
1 (Ref)
|
-
|
275 (95.5)
|
244 (92.8)
|
1 (Ref)
|
-
|
|
(NAT2*14)
|
G / A
|
58 (12.2)
|
41 (9.2)
|
0.78 (0.46 - 1.33)
|
0.364
|
13 (4.5)
|
18 (6.8)
|
1.46 (0.48 - 4.49)
|
0.508
|
|
rs1801279
|
A / A
|
1 (0.2)
|
3 (0.7)
|
−
| |
0 (0)
|
1 (0.4)
|
−
| |
|
NAT1
|
1088T>A
|
T / T
|
89 (19.2)
|
100 (22.8)
|
1 (Ref)
|
-
|
106 (37.3)
|
81 (31.4)
|
1 (Ref)
|
-
|
|
(NAT1*10)
|
T / A
|
219 (47.3)
|
196 (44.7)
|
0.77 (0.50 - 1.18)
|
0.226
|
128 (45.1)
|
130 (50.4)
|
1.64 (0.90 - 2.98)
|
0.103
|
|
rs1057126
|
A / A
|
155 (33.5)
|
142 (32.4)
|
1.07 (0.67 - 1.70)
|
0.781
|
50 (17.6)
|
47 (18.2)
|
1.57 (0.73 - 3.40)
|
0.249
|
|
1095C>A
|
C / C
|
86 (18.6)
|
95 (21.7)
|
1 (Ref)
|
-
|
97 (34.1)
|
69 (26.7)
|
1 (Ref)
|
-
|
|
(NAT1*10, NAT1*3)
|
C / A
|
220 (47.5)
|
198 (45.2)
|
0.79 (0.51 - 1.23)
|
0.299
|
130 (45.8)
|
138 (53.5)
|
1.83 (0.99 - 3.39)
|
0.054
|
|
rs15561
|
A / A
|
157 (33.9)
|
145 (33.1)
|
1.10 (0.69 - 1.75)
|
0.681
|
57 (20.1)
|
51 (19.8)
|
1.78 (0.82 - 3.84)
|
0.143
|
- Samples with unknown genotype are not shown.
- aOdds ratio was adjusted for age, gender, tobacco smoking, and alcohol consumption status; odds ratio was not calculated for subgroups with low sample size.
- *Indicates the allele for each of the genes.
