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Table 2 Genotype frequency of NAT2 and NAT1 polymorphisms and association with OSCC in Black and Mixed Ancestry South Africans

From: NAT1 and NAT2 genetic polymorphisms and environmental exposure as risk factors for oesophageal squamous cell carcinoma: a case-control study

    Black Mixed Ancestry
Gene SNP Polymorphism Controls (%) Cases (%) OR (95% CI)a P-value Controls (%) Cases (%) OR (95% CI)a P-value
NAT2 590G>A G / G 296 (62.3) 257 (57.2) 1 (Ref) - 172 (59.7) 159 (60.0) 1 (Ref) -
(NAT2*6) G / A 155 (32.6) 163 (36.3) 1.20 (0.85 - 1.69) 0.299 105 (36.4) 93 (35.1) 0.69 (0.39 - 1.21) 0.192
rs1799930 A / A 24 (5.0) 29 (6.4) 1.46 (0.72 - 2.94) 0.291 11 (3.8) 13 (4.9) 1.30 (0.34 - 4.91) 0.697
341T>C T / T 247 (52.1) 237 (53.0) 1 (Ref) - 130 (45.1) 147 (55.7) 1 (Ref) -
(NAT2*5) T / C 179 (37.8) 178 (39.8) 0.97 (0.69 - 1.36) 0.856 125 (43.4) 101 (38.2) 0.59 (0.34 - 1.04) 0.069
rs1801280 C / C 48 (10.1) 32 (7.1) 0.55 (0.30 - 0.99) 0.05 33 (11.5) 16 (6.1) 0.31 (0.11 - 0.87) 0.026
857G>A G / G 471 (98.9) 440 (98.2) 1 (Ref) - 265 (92.0) 237 (90.5) 1 (Ref) -
(NAT2*7) G / A 5 (1.0) 7 (1.6) 0.95 (0.19 - 4.77) 0.948 23 (8.0) 24 (9.2) 1.32 (0.54 - 3.23) 0.548
rs1799931 A / A 0 (0) 1 (0.2) −   0 (0) 1 (0.4) −  
191G>A G / G 417 (87.6) 402 (90.1) 1 (Ref) - 275 (95.5) 244 (92.8) 1 (Ref) -
(NAT2*14) G / A 58 (12.2) 41 (9.2) 0.78 (0.46 - 1.33) 0.364 13 (4.5) 18 (6.8) 1.46 (0.48 - 4.49) 0.508
rs1801279 A / A 1 (0.2) 3 (0.7) −   0 (0) 1 (0.4) −  
NAT1 1088T>A T / T 89 (19.2) 100 (22.8) 1 (Ref) - 106 (37.3) 81 (31.4) 1 (Ref) -
(NAT1*10) T / A 219 (47.3) 196 (44.7) 0.77 (0.50 - 1.18) 0.226 128 (45.1) 130 (50.4) 1.64 (0.90 - 2.98) 0.103
rs1057126 A / A 155 (33.5) 142 (32.4) 1.07 (0.67 - 1.70) 0.781 50 (17.6) 47 (18.2) 1.57 (0.73 - 3.40) 0.249
1095C>A C / C 86 (18.6) 95 (21.7) 1 (Ref) - 97 (34.1) 69 (26.7) 1 (Ref) -
(NAT1*10, NAT1*3) C / A 220 (47.5) 198 (45.2) 0.79 (0.51 - 1.23) 0.299 130 (45.8) 138 (53.5) 1.83 (0.99 - 3.39) 0.054
rs15561 A / A 157 (33.9) 145 (33.1) 1.10 (0.69 - 1.75) 0.681 57 (20.1) 51 (19.8) 1.78 (0.82 - 3.84) 0.143
  1. Samples with unknown genotype are not shown.
  2. aOdds ratio was adjusted for age, gender, tobacco smoking, and alcohol consumption status; odds ratio was not calculated for subgroups with low sample size.
  3. *Indicates the allele for each of the genes.
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