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Table 2 Genotype frequency of NAT2 and NAT1 polymorphisms and association with OSCC in Black and Mixed Ancestry South Africans
| Black | Mixed Ancestry | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | Polymorphism | Controls (%) | Cases (%) | OR (95% CI)a | P-value | Controls (%) | Cases (%) | OR (95% CI)a | P-value |
| NAT2 | 590G>A | G / G | 296 (62.3) | 257 (57.2) | 1 (Ref) | - | 172 (59.7) | 159 (60.0) | 1 (Ref) | - |
| (NAT2*6) | G / A | 155 (32.6) | 163 (36.3) | 1.20 (0.85 - 1.69) | 0.299 | 105 (36.4) | 93 (35.1) | 0.69 (0.39 - 1.21) | 0.192 | |
| rs1799930 | A / A | 24 (5.0) | 29 (6.4) | 1.46 (0.72 - 2.94) | 0.291 | 11 (3.8) | 13 (4.9) | 1.30 (0.34 - 4.91) | 0.697 | |
| 341T>C | T / T | 247 (52.1) | 237 (53.0) | 1 (Ref) | - | 130 (45.1) | 147 (55.7) | 1 (Ref) | - | |
| (NAT2*5) | T / C | 179 (37.8) | 178 (39.8) | 0.97 (0.69 - 1.36) | 0.856 | 125 (43.4) | 101 (38.2) | 0.59 (0.34 - 1.04) | 0.069 | |
| rs1801280 | C / C | 48 (10.1) | 32 (7.1) | 0.55 (0.30 - 0.99) | 0.05 | 33 (11.5) | 16 (6.1) | 0.31 (0.11 - 0.87) | 0.026 | |
| 857G>A | G / G | 471 (98.9) | 440 (98.2) | 1 (Ref) | - | 265 (92.0) | 237 (90.5) | 1 (Ref) | - | |
| (NAT2*7) | G / A | 5 (1.0) | 7 (1.6) | 0.95 (0.19 - 4.77) | 0.948 | 23 (8.0) | 24 (9.2) | 1.32 (0.54 - 3.23) | 0.548 | |
| rs1799931 | A / A | 0 (0) | 1 (0.2) | − | 0 (0) | 1 (0.4) | − | |||
| 191G>A | G / G | 417 (87.6) | 402 (90.1) | 1 (Ref) | - | 275 (95.5) | 244 (92.8) | 1 (Ref) | - | |
| (NAT2*14) | G / A | 58 (12.2) | 41 (9.2) | 0.78 (0.46 - 1.33) | 0.364 | 13 (4.5) | 18 (6.8) | 1.46 (0.48 - 4.49) | 0.508 | |
| rs1801279 | A / A | 1 (0.2) | 3 (0.7) | − | 0 (0) | 1 (0.4) | − | |||
| NAT1 | 1088T>A | T / T | 89 (19.2) | 100 (22.8) | 1 (Ref) | - | 106 (37.3) | 81 (31.4) | 1 (Ref) | - |
| (NAT1*10) | T / A | 219 (47.3) | 196 (44.7) | 0.77 (0.50 - 1.18) | 0.226 | 128 (45.1) | 130 (50.4) | 1.64 (0.90 - 2.98) | 0.103 | |
| rs1057126 | A / A | 155 (33.5) | 142 (32.4) | 1.07 (0.67 - 1.70) | 0.781 | 50 (17.6) | 47 (18.2) | 1.57 (0.73 - 3.40) | 0.249 | |
| 1095C>A | C / C | 86 (18.6) | 95 (21.7) | 1 (Ref) | - | 97 (34.1) | 69 (26.7) | 1 (Ref) | - | |
| (NAT1*10, NAT1*3) | C / A | 220 (47.5) | 198 (45.2) | 0.79 (0.51 - 1.23) | 0.299 | 130 (45.8) | 138 (53.5) | 1.83 (0.99 - 3.39) | 0.054 | |
| rs15561 | A / A | 157 (33.9) | 145 (33.1) | 1.10 (0.69 - 1.75) | 0.681 | 57 (20.1) | 51 (19.8) | 1.78 (0.82 - 3.84) | 0.143 | |
