Table 2 Genotype frequency of NAT2 and NAT1 polymorphisms and association with OSCC in Black and Mixed Ancestry South Africans

NAT2

590G>A

G / G

296 (62.3)

257 (57.2)

1 (Ref)

-

172 (59.7)

159 (60.0)

1 (Ref)

-

(NAT2*6)

G / A

155 (32.6)

163 (36.3)

1.20 (0.85 - 1.69)

0.299

105 (36.4)

93 (35.1)

0.69 (0.39 - 1.21)

0.192

rs1799930

A / A

24 (5.0)

29 (6.4)

1.46 (0.72 - 2.94)

0.291

11 (3.8)

13 (4.9)

1.30 (0.34 - 4.91)

0.697

341T>C

T / T

247 (52.1)

237 (53.0)

1 (Ref)

-

130 (45.1)

147 (55.7)

1 (Ref)

-

(NAT2*5)

T / C

179 (37.8)

178 (39.8)

0.97 (0.69 - 1.36)

0.856

125 (43.4)

101 (38.2)

0.59 (0.34 - 1.04)

0.069

rs1801280

C / C

48 (10.1)

32 (7.1)

0.55 (0.30 - 0.99)

0.05

33 (11.5)

16 (6.1)

0.31 (0.11 - 0.87)

0.026

857G>A

G / G

471 (98.9)

440 (98.2)

1 (Ref)

-

265 (92.0)

237 (90.5)

1 (Ref)

-

(NAT2*7)

G / A

5 (1.0)

7 (1.6)

0.95 (0.19 - 4.77)

0.948

23 (8.0)

24 (9.2)

1.32 (0.54 - 3.23)

0.548

rs1799931

A / A

0 (0)

1 (0.2)

−

0 (0)

1 (0.4)

−

191G>A

G / G

417 (87.6)

402 (90.1)

1 (Ref)

-

275 (95.5)

244 (92.8)

1 (Ref)

-

(NAT2*14)

G / A

58 (12.2)

41 (9.2)

0.78 (0.46 - 1.33)

0.364

13 (4.5)

18 (6.8)

1.46 (0.48 - 4.49)

0.508

rs1801279

A / A

1 (0.2)

3 (0.7)

−

0 (0)

1 (0.4)

−

NAT1

1088T>A

T / T

89 (19.2)

100 (22.8)

1 (Ref)

-

106 (37.3)

81 (31.4)

1 (Ref)

-

(NAT1*10)

T / A

219 (47.3)

196 (44.7)

0.77 (0.50 - 1.18)

0.226

128 (45.1)

130 (50.4)

1.64 (0.90 - 2.98)

0.103

rs1057126

A / A

155 (33.5)

142 (32.4)

1.07 (0.67 - 1.70)

0.781

50 (17.6)

47 (18.2)

1.57 (0.73 - 3.40)

0.249

1095C>A

C / C

86 (18.6)

95 (21.7)

1 (Ref)

-

97 (34.1)

69 (26.7)

1 (Ref)

-

(NAT1*10, NAT1*3)

C / A

220 (47.5)

198 (45.2)

0.79 (0.51 - 1.23)

0.299

130 (45.8)

138 (53.5)

1.83 (0.99 - 3.39)

0.054

rs15561

A / A

157 (33.9)

145 (33.1)

1.10 (0.69 - 1.75)

0.681

57 (20.1)

51 (19.8)

1.78 (0.82 - 3.84)

0.143