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Table 3 Multivariate survival analysis of comorbidities, medications and their interactions with surgery

From: Impact of comorbidities and use of common medications on cancer and non-cancer specific survival in esophageal carcinoma

 

Overall survival

EC-specific survival

Non-EC specific survival

Variables

HR(95% CI)1

P 1

HR(95% CI)2

P 2

HR(95% CI)3

P 3

Hypertension

-

-

-

-

0.94(0.66-1.33)

0.71

Interaction with surgery

-

-

-

-

1.36(0.77-2.41)

0.29

AF

-

-

-

-

1.72(1.07-2.77)

0.03

Interaction with surgery

-

-

-

-

-

-

COPD

-

-

-

-

1.43(0.88-2.38)

0.15

Interaction with surgery

-

-

-

-

-

-

Asthma

-

-

-

-

1.42(0.75-2.70)

0.28

Interaction with surgery

-

-

-

-

-

-

Hypothyroidism/ levothyroxine

0.59(0.38-0.93)

0.02

0.62(0.38-1.01)

0.05

0.78(0.44-1.37)

0.39

Interaction with surgery

2.04(1.09-3.83)

0.03

2.20(1.03-4.69)

0.04

1.50(0.61-3.69)

0.38

beta-Blocker

-

-

-

-

0.70(0.45-1.07)

0.10

Interaction with surgery

-

-

-

-

2.26(1.09-4.68)

0.03

Cardiac glycoside

1.50(0.92-2.44)

0.10

-

-

1.31(0.78-2.20)

0.30

Interaction with surgery

1.19(0.48-2.96)

0.71

-

-

-

-

Coronary vasodilator

0.93(0.54-1.61)

0.80

-

-

0.45(0.16-1.28)

0.13

Interaction with surgery

-

-

-

-

2.92(0.72-11.97)

0.13

Bronchodilator

-

-

-

-

1.89(0.98-3.62)

0.06

Interaction with surgery

-

-

-

-

-

-

Sulfonylurea

1.15(0.81-1.65)

0.43

1.28(0.79-2.07)

0.32

-

-

Interaction with surgery

-

-

0.49(0.18-1.36)

0.17

-

-

Antacid

0.94(0.79-1.12)

0.47

0.92(0.75-1.13)

0.41

0.80(0.61-1.05)

0.11

Interaction with surgery

-

-

-

-

-

-

Statin

0.92(0.76-1.11)

0.38

0.87(0.70-1.07)

0.19

-

-

Interaction with surgery

-

-

-

-

-

-

Other lipid-regulating agents

-

-

0.98(0.56-1.71)

0.94

-

-

Interaction with surgery

-

-

0.66(0.24-1.77)

0.40

-

-

  1. 1Adjusted for the interactions of age, race, tumor histology and tumor location with surgery, BMI, smoking at diagnosis, Karnofsky performance scores, tumor location, clinical stage, radiation modality and surgery for overall survival.
  2. 2Adjusted for the interactions of race, age, tumor histology and tumor location with surgery, sex, race, age, smoking at diagnosis, tumor histology, tumor length, tumor differentiation, clinical stage, radiation modality and surgery for EC-specific death free survival.
  3. 3Adjusted for the interactions of tumor histology and tumor location with surgery, age, Karnofsky performance scores, tumor histology, induction chemotherapy, radiation modality and surgery for non-EC specific death free survival.
  4. EC: esophageal carcinoma; HR: hazard rate; CI: confidence interval; AF: atrial fibrillation; COPD: chronic obstructive pulmonary disease.
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BMC Cancer

ISSN: 1471-2407

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