Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN

Table 2 Summary of mean values for PTEN S.C./A.S., USP7 and SUMO2/3 protein H-score as well as PTEN and p35 FISH ratios (R) among the different neuroendocrine histotypes

		PTEN S.C.		PTEN A.S.		USP7	SUMO2/3		PTEN	p53
		Nucl	Cyto	Nucl	Cyto	Nucl	Nucl	Cyto	FISH	FISH
	n	mean H	mean H	mean H	mean H	mean H	mean H	mean H	mean R	mean R
TC	58	218	234	168	248	226	84	72	0.96	0.90
AC	42	215	237	171	260	234	91	64	0.96	0.84
LCNEC	32	86	114	56	104	178	171	139	0.90	0.81
SCLC	60	49	163	42	146	145	152	137	0.90	0.79
All 4 histotypes	p	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001
	tau	−0.556	−0.314	−0.464	−0.392	−0.324	0.297	0.272	−0.149	−0.333
Low vs. high grade	p	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001
	tau	−0.621	−0.429	−0.540	−0.520	−0.371	0.370	0.350	−0.206	−0.307
TC vs. AC	p	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.	<0.001
	tau									−0.280
LCNEC vs. SCLC	p	0.006	0.003	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.
	tau	−0.244	0.243

Correlation with categorized 4 histotypes, only low vs. high grade, only TC vs. AC and only LCNEC vs. SCLC. p = p-value, tau = correlation coefficient, n.s. = not significant.

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