Table 3 Univariate analysis of factors predictive for Local PFS
From: Local control in metastatic neuroblastoma in children over 1 year of age
Pts | Local PFS | 95% CI | Univariate analysis | ||
|---|---|---|---|---|---|
% | Pvalue | ||||
Age | 12-18 months | 11 | 100 | - | 0.04 |
>18 months | 47 | 63 | 42-76 | ||
Site of Metastasis | Bone /Bone Marrow/ Lymph-node | 48 | 75 | 56-86 | 0.07 |
Lymph-node alone | 3 | 100 | - | ||
Others | 7 | 27 | 1-69 | ||
Primary Sites | Retroperitoneal | 12 | 59 | 16-86 | 0.50 |
Adrenal Gland | 41 | 76 | 55-88 | ||
Thorax | 5 | 60 | 13-88 | ||
MYCN | Amplified | 19 | 51 | 23-74 | 0.00 |
(available for 56 pt) | Non-amplified or MYCN gain | 37 | 80 | 59-91 | |
Inducion CT | ICE/CECAT | 21 | 55 | 28-76 | 0.12 |
Topo NB | 37 | 83 | 53-93 | ||
Primary Tumor Reduction before Surgery* | <50% | 35 | 78 | 54-90 | 0.04 |
>50%, <90% | 4 | 50 | 1-91 | ||
>90% | 12 | 47 | 17-72 | ||
Surgery | Radical | 45 | 68 | 49-81 | 0.35 |
Not Radical | 13 | 90 | 47-99 | ||
Response before HDC** | CR/VGPR | 21 | 86 | 62-95 | <0.001 |
PD | 11 | 0 | - | ||
PR | 24 | 64 | 34-83 | ||
RT | Yes | 28 | 100 | - | <0.001 |
No | 30 | 48 | 27-67 |