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Table 1 Candidate driver mutations affecting characteristics of ovarian cancer

From: Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing

Type

Genomic position (hg19)

Base change

Gene

Amino acid change

Predicted as damaging†

COSMIC (ID)

Common

chr17:7578190

T>C

TP53

Y220C

7/7

COSM99720

chr6:17781485

C>T

KIF13A

G1198S

6/7

-

chr14:25044511

G>A

CTSG

R55*

N/A

-

chr15:92459643

T>C

SLCO3A1

Y201H

6/7

-

chr12:101880256

G>A

SPIC

E152K

2/7

COSM458288

Shared (P1, M)

chr10:28905209

T>G

WAC

L555*

N/A

-

chr14:24879362

G>T

NYNRIN

G788*

N/A

-

chr21:37710167

G>T

MORC3

G128V

6/7

-

chr1:154184966

C>G

C1orf43

D159H

6/7

-

chr4:154626187

A>G

TLR2

S710G

6/7

-

chr12:52183202

G>C

SCN8A

K1432N

6/7

-

chr14:23886761

G>C

MYH7

S1435C

6/6

-

chr1:11594572

G>A

PTCHD2

W1170*

N/A

-

chr12:20799431

C>A

PDE3A

N753K

6/7

-

chr2:196545035

G>T

SLC39A10

G90V

6/7

-

Cluster P1-specific

chr1:43317062

T>G

ZNF691

C176G

6/7

-

chr13:113893782

G>T

CUL4A

D318Y

6/7

-

chr6:117892084

C>A

GOPC

G276V

6/7

-

chr11:134090616

C>A

NCAPD3

W23C

6/7

-

Cluster M- specific

chr1:206944347

T>C

IL10

M95V

5/7

-

chr2:242690697

C>G

D2HGDH

S345C

7/7

-

Cluster P2-specific

chr15:80866542

C>G

ARNT2

S457*

N/A

-

chr8:72211468

C>G

EYA1

D214H

7/7

-

chr3:101371645

T>G

ZBTB11

H816P

7/7

-

chr10:6528056

A>T

PRKCQ

C281S

7/7

-

  1. †Predicted as damaging = (the number of algorithms predicting a damaging mutation)/(the number of available algorithms). The prediction algorithms and their cutoffs were described in the Methods.
  2. *Stop codon.
  3. N/A = not available.