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Table 3 Estimates from generalized linear mixed model fit to 5FU concentrations (ng/ml)

From: Circadian variation in plasma 5-fluorouracil concentrations during a 24 hour constant-rate infusion

Parameter Estimate 95% CI
Dose (mg/m2)
 1800 vs. 1000 0.292 (0.076, 0.508)
 2600 vs. 1000 0.628 (0.429, 0.827)
Elapsed time (hours)
 1000 mg/m2 0.002 (−0.003, 0.007)
 1800 mg/m2 0.013 (0.008, 0.017)
 2600 mg/m2 0.018 (0.014, 0.022)
Infusion (2 vs. 1) 0.072 (−0.002, 0.147)
Time of day§
 00:00 0.033 (−0.005, 0.071)
 03:00 0.058 (0.019, 0.096)
 06:00 0.091 (0.039, 0.142)
 09:00 −0.000 (−0.039, 0.038)
 12:00 −0.018 (−0.056, 0.020)
 15:00 −0.089 (−0.128, −0.049)
 18:00 −0.040 (−0.094, 0.014)
 21:00 −0.034 (−0.073, 0.005)
Constant 5.958 (5.794, 6.122)
SD of patient-level effects 0.264 (0.207, 0.338)
SD of within-patient, infusion effects 0.174 (0.136, 0.223)
Coefficient of variation 0.210 (0.198, 0.221)
  1. Generalized linear mixed model with log link and gamma variance function (i.e., constant coefficient of variation), fit to q3hr 5FU concentrations during first two 24 hr infusions. Model includes random effects for patient and infusion within patient.
  2. §Parameters sum to zero, thus reflecting deviations from the linear trend over time within a single infusion.