Table 3 Estimates from generalized linear mixed model † fit to 5FU concentrations (ng/ml)
From: Circadian variation in plasma 5-fluorouracil concentrations during a 24 hour constant-rate infusion
Parameter | Estimate | 95% CI |
|---|---|---|
Dose (mg/m2) | ||
1800 vs. 1000 | 0.292 | (0.076, 0.508) |
2600 vs. 1000 | 0.628 | (0.429, 0.827) |
Elapsed time (hours) | ||
1000 mg/m2 | 0.002 | (−0.003, 0.007) |
1800 mg/m2 | 0.013 | (0.008, 0.017) |
2600 mg/m2 | 0.018 | (0.014, 0.022) |
Infusion (2 vs. 1) | 0.072 | (−0.002, 0.147) |
Time of day§ | ||
00:00 | 0.033 | (−0.005, 0.071) |
03:00 | 0.058 | (0.019, 0.096) |
06:00 | 0.091 | (0.039, 0.142) |
09:00 | −0.000 | (−0.039, 0.038) |
12:00 | −0.018 | (−0.056, 0.020) |
15:00 | −0.089 | (−0.128, −0.049) |
18:00 | −0.040 | (−0.094, 0.014) |
21:00 | −0.034 | (−0.073, 0.005) |
Constant | 5.958 | (5.794, 6.122) |
SD of patient-level effects | 0.264 | (0.207, 0.338) |
SD of within-patient, infusion effects | 0.174 | (0.136, 0.223) |
Coefficient of variation | 0.210 | (0.198, 0.221) |