Figure 2

Observed 5FU concentrations (in ng/ml, labeled with cycle number and connected by gray lines) together with fitted values from a generalized linear mixed model (solid black lines) for four selected patients (two cycles each). Fitted values include empirical Bayes (posterior means) estimates of random effects for patient and for cycle within patient. Dashed lines indicate the period between midnight and 6 a.m. when highest average 5-FU concentrations were observed.