Figure 1
From: Circadian variation in plasma 5-fluorouracil concentrations during a 24 hour constant-rate infusion
Estimated changes in mean 5FU concentration (ng/ml) with time of day, obtained by fitting a generalized linear mixed model (GLMM) to the data from 61 patients (two 24-hr infusions each). Panel A shows estimates for the overall sample, together with 95% confidence intervals. Panel B shows estimates for three cohorts, from a model adding cohort and an interaction between cohort and time of day. Panel C shows estimates for men and women, from a model adding sex and an interaction between sex and time of day.