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Table 3 Univariateand multivariate analyses for survival predictors in the elderly with brain metastasis after GKRS

From: Gamma knife radiosurgery for elderly patients with brain metastases: evaluation of scoring systems that predict survival

Variable No. of patients Survival days (median±SD) Univariate analysis Multivariate analysis
Pvalue HR 95% CI Pvalue
Characteristics of systemic cancer
Sex    0.115 ND 0.259
 Female 39 212 ± 86.8
 Male 108 156 ± 26.4
Age    0.780 ND 0.554
 70 - 75 80 199 ± 26.3
 ≥75 67 130 ± 23.5
KPS    0.047 1.539 1.089-2.173 0.014
 ≤80 62 125 ± 19.7
 ≥90 85 199 ± 21.2
Origin cancer    0.032 ND 0.070
 Lung 117 171 ± 27.9
 Non-lung or ND 30 110 ± 20.5
Primary cancer status    0.488 ND 0.980
 Non-PD 45 171 ± 27.6
 PD 102 141 ± 32.1
Extracranial metastasis    0.032 0.633 0.445-0.900 0.011
 No 56 189 ± 35.5
 Yes 91 141 ± 19.9
Characteristics of brain metastasis
Presentation type    0.289 ND 0.646
 Synchronous 65 141 ± 21.1
 Metachronous 82 188 ± 26.3
Number of metastasis    0.247 ND 0.235
 Single 61 209 ± 25.7
 Multiple 86 141 ± 17.7
Volume of the largest lesion (cc)    0.179 ND 0.410
 <13 126 167 ± 30.1
 ≥13 21 171 ± 59.5
Infratentorial/brainstem involvement    0.411 ND 0.363
 No 95 156 ± 26.1
 Yes 52 188 ± 42.7
Sequential systemic chemotherapy    0.257 ND 0.148
 No 92 143 ± 18.7
 Yes 55 212 ± 26.5
Scoring system
RPA class    0.613   NA  
 II 126 167 ± 30.5     
 III 21 170 ± 58.7     
SIR score    0.024   NA  
 Low (1–3) 42 130 ± 7.0     
 High (4–7) 105 209 ± 24.7     
GPA score    0.001   NA  
 Low (0–1.5) 77 128 ± 14.9     
 High (2–4) 70 213 ± 22.0     
BSBM score    0.273   NA  
 Low (0–1) 58 141 ± 17.1     
 High (2–3) 89 207 ± 21.7