Gamma knife radiosurgery for elderly patients with brain metastases: evaluation of scoring systems that predict survival

Table 3 Univariateand multivariate analyses for survival predictors in the elderly with brain metastasis after GKRS

Variable	No. of patients	Survival days (median±SD)	Univariate analysis	Multivariate analysis
Variable	No. of patients	Survival days (median±SD)	Pvalue	HR	95% CI	Pvalue
Characteristics of systemic cancer
Sex			0.115	ND		0.259
Female	39	212 ± 86.8
Male	108	156 ± 26.4
Age			0.780	ND		0.554
70 - 75	80	199 ± 26.3
≥75	67	130 ± 23.5
KPS			0.047	1.539	1.089-2.173	0.014
≤80	62	125 ± 19.7
≥90	85	199 ± 21.2
Origin cancer			0.032	ND		0.070
Lung	117	171 ± 27.9
Non-lung or ND	30	110 ± 20.5
Primary cancer status			0.488	ND		0.980
Non-PD	45	171 ± 27.6
PD	102	141 ± 32.1
Extracranial metastasis			0.032	0.633	0.445-0.900	0.011
No	56	189 ± 35.5
Yes	91	141 ± 19.9
Characteristics of brain metastasis
Presentation type			0.289	ND		0.646
Synchronous	65	141 ± 21.1
Metachronous	82	188 ± 26.3
Number of metastasis			0.247	ND		0.235
Single	61	209 ± 25.7
Multiple	86	141 ± 17.7
Volume of the largest lesion (cc)			0.179	ND		0.410
<13	126	167 ± 30.1
≥13	21	171 ± 59.5
Infratentorial/brainstem involvement			0.411	ND		0.363
No	95	156 ± 26.1
Yes	52	188 ± 42.7
Sequential systemic chemotherapy			0.257	ND		0.148
No	92	143 ± 18.7
Yes	55	212 ± 26.5
Scoring system
RPA class			0.613		NA
II	126	167 ± 30.5
III	21	170 ± 58.7
SIR score			0.024		NA
Low (1–3)	42	130 ± 7.0
High (4–7)	105	209 ± 24.7
GPA score			0.001		NA
Low (0–1.5)	77	128 ± 14.9
High (2–4)	70	213 ± 22.0
BSBM score			0.273		NA
Low (0–1)	58	141 ± 17.1
High (2–3)	89	207 ± 21.7

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