Significant correlation between urinary N1, N12-diacetylspermine and tumor invasiveness in patients with clinical stage IA non-small cell lung cancer

Table 2 Correlation between urine DiAcSpm and clinicopathological factors

Factors	Urine DiAcSpm level (nmol/g creatinine)		p-value *
	Low	High
Age (years)
≤69	47	40
>69	38	46	0.286
Smoking history
Never-smoker	32	26
Smoker	53	60	0.335
Tumor size (cm)
≤2.0	55	49
>2.0	30	37	0.348
Serum CEA level (mg/dL)
≤5.0	79	69
>5.0	6	17	0.023
TDR
≥0.75	25	24
<0.75	60	62	0.867
Histological type
adenocarcinoma	68	69
non-adenocarcinoma	17	17	0.970
Lymph node metastasis
N0	82	75
N1-2	3	11	0.048
Lymphatic permeation
negative	78	69
positive	7	17	0.046
Vascular invasion
negative	73	59
positive	12	27	0.010
Pleural invasion
pl0	75	70
pl1-2	10	16	0.287

*Fisher’s exact test, DiAcSpm = diacetylspermine, CEA = carcinoembryonic antigen level.

ISSN: 1471-2407