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Figure 3 | BMC Cancer

Figure 3

From: Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model

Figure 3

Effects on VEGF-A secretion by cMET inhibition. A) cMET inhibition had no effect on constitutive or DFX-induced VEGF-A secretion by HPAF-II pancreatic cancer cells (#P < 0.05). B) MiaPaCa2(G250) showed a significant increase in VEGF-A production compared to MiaPaCa2(par) (#P < 0.05). However, INC280 has no effect on constitutive VEGF-A secretion in either MiaPaCa2(par) or gemcitabine-resistant MiaPaCa2(G250). C) Hypoxia-mimicking DFX significantly induced VEGF-A secretion from MiaPaCa2(G250) (#P < 0.05). Targeting cMET significantly impaired this effect (*P < 0.05). Bars = SEM.

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BMC Cancer

ISSN: 1471-2407

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