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Table 2 Univariate and multivariate analysis of overall survival in breast cancer patients

From: Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion

A. Univariate analysis
Parameter P Hazard ratio 95% CI
S100A14 (positive vs negative) <0.001 3.315 1.777 to 6.813
S100A16 (positive vs negative) <0.001 2.947 1.640 to 5.927
Co-expression of S100A14 and S100A16 (yes vs no) <0.001 3.678 2.029 to 6.666
Age (<60 vs ≥ 60 years) 0.475 0.788 0.660 to 2.439
Tumor size (≥2 cm vs < 2 cm) 0.852 1.060 0.576 to 1.951
Lymph node metastasis (yes vs no) <0.001 2.746 1.770 to 4.261
ER (negative vs positive) 0.003 2.351 1.333 to 4.143
PgR (negative vs positive) 0.040 1.948 1.030 to 3.685
HER2 score (2,3 vs 0,1) <0.001 2.680 1.492 to 4.815
Histological grade (3 vs 1,2) <0.001 4.782 2.653 to 8.618
    NS: not significant
B. Multivariate analysis including each S100A14 and S100A16 expression
Parameter P Hazard ratio 95% CI
S100A14 (positive vs negative) <0.001 3.397 1.807
S100A16 (positive vs negative) NS   
Age (<60 vs ≥ 60 years) NS   
Tumor size (≥2 cm vs < 2 cm) NS   
Lymph node metastasis (yes vs no) NS   
ER (negative vs positive) NS   
PgR (negative vs positive) 0.024 2.107 1.104 to 4.021
HER2 score (2,3 vs 0,1) NS   
Histological grade (3 vs 1,2) <0.001 4.316 2.383 to 7.817
    NS: not significant
C. Multivariate analysis including coexpression of S100A14 and S100A16
Parameter P Hazard ratio 95% CI
Co-expression of S100A14 and S100A16 (yes vs no) 0.001 2.811 1.529 to 5.170
Age (<60 vs ≥ 60 years) NS   
Tumor size (≥2 cm vs < 2 cm) NS   
Lymph node metastasis (yes vs no) NS   
ER (negative vs positive) NS   
PgR (negative vs positive) 0.049 1.907 1.004 to 3.623
HER2 score (2,3 vs 0,1) NS   
Histological grade (3 vs 1,2) <0.001 3.970 2.175 to 7.247
    NS: not significant