Table 1 Association between clinicopathological variables and S100A14 and S100A16
Clinical data | S100A14 | Â | S100A16 | Â | S100A14 and S100A16 | Â | |||
|---|---|---|---|---|---|---|---|---|---|
Low expression | High expression | Â | Low expression | High expression | Â | Low expression | High expression | Â | |
P | P | P | |||||||
n = 84 (%) | n = 83 (%) | Â | n = 132 (%) | n = 35 (%) | Â | n = 137 (%) | n = 30 (%) | Â | |
Patient age (y) | Â | Â | Â | Â | Â | Â | Â | Â | Â |
<60 | 53(31.7) | 65(38.9) | 0.047* | 88(52.7) | 30(18.0) | 0.046* | 93(55.7) | 25(15.0) | 0.025* |
≥60 | 31(18.6) | 18(10.8) |  | 44(26.3) | 5(3.0) |  | 44(26.3) | 5(3.0) |  |
pT | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 | 29(17.4) | 20(12.0) | 0.183 | 46(27.5) | 3(1.8) | 0.007§ | 47(28.1) | 2(1.2) | 0.07 |
2 | 49(29.3) | 52(31.1) | Â | 73(43.7) | 28(16.8) | Â | 77(46.1) | 24(14.4) | Â |
3 | 6(3.6) | 8(4.8) | Â | 11(6.6) | 3(1.8) | Â | 11(6.6) | 3(1.8) | Â |
4 | 0(0) | 3(1.8) | Â | 2(1.2) | 1(0.6) | Â | 2(1.2) | 1(0.6) | Â |
pN | Â | Â | Â | Â | Â | Â | Â | Â | Â |
0 | 30(18.0) | 22(13.2) | 0.153 | 51(30.5) | 1(0.6) | <0.001§ | 51(30.5) | 1(0.6) | 0.005§ |
1 | 50(29.9) | 50(29.9) | Â | 71(42.5) | 29(17.4) | Â | 76(45.5) | 24(14.4) | Â |
2 | 4(2.4) | 10(6.0) | Â | 10(6.0) | 4(2.4) | Â | 10(6.0) | 4(2.4) | Â |
3 | 0(0) | 1(0.6) | Â | 0(0) | 1(0.6) | Â | 0(0) | 1(0.6) | Â |
TNM staging | Â | Â | Â | Â | Â | Â | Â | Â | Â |
I | 25(15.0) | 15(9.0) | 0.126 | 37(22.2) | 3(1.8) | 0.067 | 37(22.2) | 3(1.8) | 0.214 |
II | 50(29.9) | 50(29.9) | Â | 75(44.9) | 25(15.0) | Â | 80(47.9) | 20(12.0) | Â |
III | 8(4.8) | 14(8.4) | Â | 16(9.6) | 6(3.6) | Â | 16(9.6) | 6(3.6) | Â |
IV | 1(0.6) | 4(2.4) | Â | 4(2.4) | 1(0.6) | Â | 4(2.4) | 1(0.6) | Â |
Histological grade | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 | 26(15.6) | 13(7.8) | 0.069 | 33(19.8) | 6(3.6) | 0.433 | 36(21.6) | 3(1.8) | 0.147 |
2 | 36(21.6) | 43(25.7) | Â | 63(37.7) | 16(9.6) | Â | 65(38.9) | 14(8.4) | Â |
3 | 22(13.2) | 27(16.2) | Â | 36(21.6) | 13(7.8) | Â | 36(21.6) | 13(7.8) | Â |
ER | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Negative | 23(13.8) | 39(23.4) | 0.014* | 43(25.7) | 19(11.4) | 0.030* | 44(26.3) | 18(10.8) | 0.008* |
Positive | 61(36.5) | 44(26.3) | Â | 89(53.3) | 16(9.6) | Â | 93(55.7) | 12(7.2) | Â |
PgR | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Negative | 53(31.9) | 50(29.9) | 0.826 | 80(47.9) | 23(13.8) | 0.721 | 83(49.7) | 20(12.0) | 0.618 |
Positive | 31(18.7) | 33(19.9) | Â | 52(31.1) | 12(7.2) | Â | 54(32.3) | 10(6.0) | Â |
HER2 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
score 0 & 1 | 76(45.4) | 56(33.1) | 0.001* | 114(68.3) | 18(10.8) | <0.001* | 118(70.7) | 14(8.4) | <0.001* |
score 2 & 3 | 8(4.9) | 27(16.6) | Â | 18(10.8) | 17(10.2) | Â | 19(11.4) | 16(.96) | Â |
S100A16 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
low | 79(47.3) | 53(31.7) | <0.001* | Â | Â | Â | Â | Â | Â |
high | 5(3.0) | 30(18.0) | Â | Â | Â | Â | Â | Â | Â |