|
Patient 1
|
43/M
|
high risk
|
46,XY,t(9;22)(q34;q11)[20]
|
CP CML
|
0
|
37432
|
wildtype
|
ND
|
| | | |
ND
|
CP CML
|
7
|
32703
|
T315I (3.9%)
|
wildtype
|
| | | |
ND
|
CP CML
|
9
|
30251
|
T315I (53,5%)
|
ND
|
|
Patient 2
|
70/M
|
high risk
|
46,XY,t(9;22)(q34;q11)[25]
|
CP CML
|
0
|
23089
|
wildtype
|
ND
|
| | | |
46,XY,t(9;22)(q34;q11)[19]/
| |
6
|
27633
|
wildtype
|
ND
|
| | | |
46,XY,t(9;22)(q34;q11)[4]/46,XY,idem,del(11)(q14)[16]
|
AP CML
|
43
|
34467
|
wildtype
|
wildtype
|
| | | |
ND but later sample shows 46,XY,t(9;22)(q34;q11)del(11)(q14)[20]
| |
64
|
41963
|
T315I (98%)
|
T315I
|
|
Patient 3
|
65/M
|
high risk
|
46,XY,t(9;22)(q34;q11)[25]
|
CP CML
|
0
|
35377
|
wildtype
|
ND
|
| | | |
46,XY,t(9;22)(q34;q11)[24]/46,XY[1]
|
CP CML
|
3
| |
wildtype
|
ND
|
| | | |
46,XY,t(9;22)(q34;q11)[6]/47sl,i(17)(q10),add(20)(p13),+mar[4]/46,XY[10]
|
AP CML
|
49
|
39685
|
T315I (88,9%), F359C (4,2%)
|
T315I
|
| | | |
46,XY,t(9;22)(q34;q11)[3]/46,XY,del(5q)[6]/46,XY[10]
|
AP CML
|
55
|
42642
|
T315I (94,8%), F359C (2,2%), D276G (1,8%), H396R (1%)
|
T315I
|
|
Patient 4
|
61/F
|
high risk
|
46,XX,t(9;22)(q34;q11)[25]
|
CP AML
|
0
|
36658
|
wildtype
|
ND
|
| | | |
46,XX[20]
|
CP CML
|
111
|
41922
|
F359I (83,1%), T315I (13,5%)
|
F359I, T315I
|
|
Patient 5
|
66/M
| |
ND
|
CP CML
|
0
|
24062
|
wildtype
|
ND
|
| | | |
46,XY,del(6)(q2?1;q2?3),-7,t(9;22)(q34;q11)[20]
|
Blast crisis
|
4
|
28446
|
Y253H (94,8%), E255V (1,8%)
|
Y253H
|
|
Patient 6
|
65/M
| |
46,XY,t(9;22)(q34;q11)[20]
|
CP CML
|
0
|
32982
|
wildtype
|
ND
|
| | | |
46,XY,t(9;22)(q34;q11)[11]/
|
CP CML
|
7
|
29221
|
4 isoforms
|
wildtype
|
| | | |
46,XY[20]
|
CP CML
|
13
|
34726
|
3 isoforms
|
ND
|
