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Table 1 Characteristics of the patient samples included in this study

From: Clonal distribution of BCR-ABL1 mutations and splice isoforms by single-molecule long-read RNA sequencing

  Age/sex Sokal score Karyotype Diagnosis Time after diag (m) CCS reads PacBio results Sanger results
Patient 1 43/M high risk 46,XY,t(9;22)(q34;q11)[20] CP CML 0 37432 wildtype ND
    ND CP CML 7 32703 T315I (3.9%) wildtype
    ND CP CML 9 30251 T315I (53,5%) ND
Patient 2 70/M high risk 46,XY,t(9;22)(q34;q11)[25] CP CML 0 23089 wildtype ND
    46,XY,t(9;22)(q34;q11)[19]/   6 27633 wildtype ND
    46,XY,t(9;22)(q34;q11)[4]/46,XY,idem,del(11)(q14)[16] AP CML 43 34467 wildtype wildtype
    ND but later sample shows 46,XY,t(9;22)(q34;q11)del(11)(q14)[20]   64 41963 T315I (98%) T315I
Patient 3 65/M high risk 46,XY,t(9;22)(q34;q11)[25] CP CML 0 35377 wildtype ND
    46,XY,t(9;22)(q34;q11)[24]/46,XY[1] CP CML 3   wildtype ND
    46,XY,t(9;22)(q34;q11)[6]/47sl,i(17)(q10),add(20)(p13),+mar[4]/46,XY[10] AP CML 49 39685 T315I (88,9%), F359C (4,2%) T315I
    46,XY,t(9;22)(q34;q11)[3]/46,XY,del(5q)[6]/46,XY[10] AP CML 55 42642 T315I (94,8%), F359C (2,2%), D276G (1,8%), H396R (1%) T315I
Patient 4 61/F high risk 46,XX,t(9;22)(q34;q11)[25] CP AML 0 36658 wildtype ND
    46,XX[20] CP CML 111 41922 F359I (83,1%), T315I (13,5%) F359I, T315I
Patient 5 66/M   ND CP CML 0 24062 wildtype ND
    46,XY,del(6)(q2?1;q2?3),-7,t(9;22)(q34;q11)[20] Blast crisis 4 28446 Y253H (94,8%), E255V (1,8%) Y253H
Patient 6 65/M   46,XY,t(9;22)(q34;q11)[20] CP CML 0 32982 wildtype ND
    46,XY,t(9;22)(q34;q11)[11]/ CP CML 7 29221 4 isoforms wildtype
    46,XY[20] CP CML 13 34726 3 isoforms ND