Association of PALB2 sequence variants with the risk of familial and early-onset breast cancer in a South-American population

Table 5 Haplotype effects for rs152451 and rs45551636 PALB2 variants

		All BC cases (n = 436)			Families with ≥ 2 BC and/or OC cases (n = 273)			Families with ≥ 3 BC and/or OC cases (n = 124)			Single affected, diagnosis ≤ 50 years (n = 163)
Haplotype	Controls (%) (n = 809)	BC cases (%)	Pvalue^a	OR [95% CI]	BC cases (%)	Pvalue^a	OR [95% CI]	BC cases (%)	Pvalue^a	OR [95% CI]	BC cases (%)	Pvalue^a	OR [95% CI]
A-C	1475 (91.2%)	781 (89.6%)	-	1.0 (1.0-1.0)	480 (87.9%)	-	1.0 (1.0-1.0)	209 (84.3%)	-	1.0 (ref)	301 (92.3%)	-	1.0 (1.0-1.0)
G-C	120 (7.4%)	67 (7.7%)	0.75	1.1 (0.8-1.4)	47 (8.6%)	0.31	1.2 (0.8-1.7)	27 (10.9%)	0.05	1.6 (1.0-2.5)	20 (6.1%)	0.48	0.8 (0.5-1.3)
G-T	23 (1.4%)	24 (2.8%)	0.03	2.0 (1.1-3.5)	19 (3.5%)	0.004	2.5 (1.4-4.7)	12 (4.8%)	<0.001	3.7 (1.8-7.5)	5 (1.5%)	0.80	1.1 (0.4-2.8)

ISSN: 1471-2407