ELISA assays of the IFN-β (A), TNF-α (B), IL-6 (C), and IL-8(D) levels. Supernatants of ovarian samples (n = 20/group) displaying papillary carcinoma were assessed 60 days after the final dose of mel. aP < 0.01 vs. OC. IFN-β: interferon-β; TNF-α: tumor necrosis factor alpha; IL-6: interleukin-6; IL-8: interleukin-8. All results are expressed as the means ± SD. Two-way ANOVA followed by Tukey test was performed.