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Table 1 Summary of the clinocopathologic variables in the cohort’s clinicopathologic variables within cardia and non-cardia adenocarcinomas

From: Retrospective review using targeted deep sequencing reveals mutational differences between gastroesophageal junction and gastric carcinomas

Clinicopathologic variable Gastroesophageal junction (n = 92) Non-cardia (n = 75) Overall (n = 167) p
Age (mean, years) 61.5 +/- 9.6 [33-80] 66.3 +/- 11.9 [33-84] 63.7 +/- 10.9 [33-84] 0.001
Sex     0.297
Male 70 (76) 51 (68) 121 (73)
Female 22 (24) 24 (32) 46 (27)
Histologic subtype (Lauren)     0.008
Intestinal 65 (71) 36 (48) 101 (60)
Diffuse 15 (16) 26 (35) 41 (25)
Mixed 12 (13) 13 (17) 25 (15)
Stage (AJCC)     0.031
IA-B 10 (11) 19 (25) 29 (17)
IIA-B 60 (65) 45 (60) 105 (63)
III-A-C 22 (24) 11 (15) 33 (20)
Grade     0.415
Well differentiated (G1)   4 (5) 10 (6)
Moderately differentiated (G2) 39 (42) 25 (33) 64 (38)
Poorly differentiated (G3) 47 (51) 46 (61) 93 (56)
Resection margin     0.306
Uninvolved 74 (80) 65 (87) 139 (83)
Involved 18 (20) 10 (13) 28 (17)
ERBB2 amplification     0.654
Absent 78 (85) 66 (88) 144 (86)
Present 14 (15) 9 (12) 23 (14)
BAF250a ( ARID1A ) expression     0.111
Intact 73 (79) 51 (68) 124 (74)
Absent 19 (21) 24 (32) 43 (26)
p53 expression     2.8x10 -4
0 – absent 32 (35) 47 (63) 79 (47)
1 – normal (1-60%) 17 (19) 14 (19) 31 (19)
2 - increased (>60%) 43 (47) 14 (19) 57 (34)
Mismatch repair proteins     0.244
Intact 77 (84) 57 (76) 135 (80)
Abnormal 15 (16) 18 (24) 33 (20)
Number of recurrences 57 (62) 32 (43) 89 (53) 0.019
Median progression-free survival (Months) 12 18 15  
Number of deaths 69 (75) 48 (64) 117 (70) 0.130
Median overall survival (Months) 18.0 23.0 20.0