Table 1 Summary of the clinocopathologic variables in the cohort’s clinicopathologic variables within cardia and non-cardia adenocarcinomas
Clinicopathologic variable | Gastroesophageal junction (n = 92) | Non-cardia (n = 75) | Overall (n = 167) | p |
|---|---|---|---|---|
Age (mean, years) | 61.5 +/- 9.6 [33-80] | 66.3 +/- 11.9 [33-84] | 63.7 +/- 10.9 [33-84] | 0.001 |
Sex | Â | Â | Â | 0.297 |
Male | 70 (76) | 51 (68) | 121 (73) | |
Female | 22 (24) | 24 (32) | 46 (27) | |
Histologic subtype (Lauren) | Â | Â | Â | 0.008 |
Intestinal | 65 (71) | 36 (48) | 101 (60) | |
Diffuse | 15 (16) | 26 (35) | 41 (25) | |
Mixed | 12 (13) | 13 (17) | 25 (15) | |
Stage (AJCC) | Â | Â | Â | 0.031 |
IA-B | 10 (11) | 19 (25) | 29 (17) | |
IIA-B | 60 (65) | 45 (60) | 105 (63) | |
III-A-C | 22 (24) | 11 (15) | 33 (20) | |
Grade | Â | Â | Â | 0.415 |
Well differentiated (G1) | Â | 4 (5) | 10 (6) | |
Moderately differentiated (G2) | 39 (42) | 25 (33) | 64 (38) | |
Poorly differentiated (G3) | 47 (51) | 46 (61) | 93 (56) | |
Resection margin | Â | Â | Â | 0.306 |
Uninvolved | 74 (80) | 65 (87) | 139 (83) | |
Involved | 18 (20) | 10 (13) | 28 (17) | |
ERBB2 amplification | Â | Â | Â | 0.654 |
Absent | 78 (85) | 66 (88) | 144 (86) | |
Present | 14 (15) | 9 (12) | 23 (14) | |
BAF250a ( ARID1A ) expression | Â | Â | Â | 0.111 |
Intact | 73 (79) | 51 (68) | 124 (74) | |
Absent | 19 (21) | 24 (32) | 43 (26) | |
p53 expression | Â | Â | Â | 2.8x10 -4 |
0 – absent | 32 (35) | 47 (63) | 79 (47) | |
1 – normal (1-60%) | 17 (19) | 14 (19) | 31 (19) | |
2 - increased (>60%) | 43 (47) | 14 (19) | 57 (34) | |
Mismatch repair proteins | Â | Â | Â | 0.244 |
Intact | 77 (84) | 57 (76) | 135 (80) | |
Abnormal | 15 (16) | 18 (24) | 33 (20) | |
Number of recurrences | 57 (62) | 32 (43) | 89 (53) | 0.019 |
Median progression-free survival (Months) | 12 | 18 | 15 | Â |
Number of deaths | 69 (75) | 48 (64) | 117 (70) | 0.130 |
Median overall survival (Months) | 18.0 | 23.0 | 20.0 | Â |