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Table 4 ES - SBA - overall survival BY prognostic factors

From: Prognostic factors and treatment outcomes in patients with Small Bowel Adenocarcinoma (SBA): The Royal Marsden Hospital (RMH) experience

   Number events/Number subjects 5 Year survival (95% CI) Hazard ratio (95% CI) p-value
Gender Male 15/28 41.0 (19.8 – 62.2) 1.81 (0.79 – 4.15) 0.160
  Female 9/20 55.5 (33.2 – 76.8) -  
Primary tumour Duodenum 12/30 60.3 (40.9 – 79.7) - (0.046)
  Jejunum 7/10 30.0 (1.6 – 58.4) 1.61 (0.63 – 4.11) 0.316
  Ileum 4/7 33.3 (0 – 70.9) 1.97 (0.63 – 6.22) 0.246
  Small bowel unknown 1/1 0 28.4 (2.48 – 326.5) 0.007
Grade Low/(differentiation) 10/27 56.9 (36.7 – 77.1) -  
Moderate Poor 14/20 34.8 (12.7 – 56.9) 2.58 (1.13 – 5.89) 0.025
Nodes harvested <12 12/21 42.9 (21.7 – 64.1) -  
  ≥12 6/16 69.6 (44.3 – 94.9) 0.75 (0.28 – 2.01) 0.572
Nodes involved Negative (Stage I/II) 13/30 49.7 (30.1 – 69.3) -  
  Positive (Stage III) 9/12 41.7 (13.9 – 69.5) 1.64 (0.70 – 3.84) 0.259
LVI No 3/18 78.6 (57.0 – 100) -  
  Yes 17/22 30.0 (10.4 – 49.6) 6.73 (1.95 – 23.2) 0.003
PNI No 13/29 51.4 (31.4 – 71.4) -  
  Yes 7/11 45.5 (16.1 – 74.9) 1.42 (0.56 – 3.55) 0.460
Adjuvant Chemo No 10/21 42.0 (18.5 – 65.5) -  
  Yes 14/27 52.1 (32.3 – 71.9) 0.93 (0.41 – 2.11) 0.867
Small Bowel Obstruction None 13/28 46.9 (26.9 – 66.9) -  
  Present 5/8 29.2 (0 – 63.1) 1.75 (0.62 – 4.97) 0.294
Weight loss None 14/29 45.0 (25.6 – 64.4) -  
  Present 4/7 33.3 (0 – 70.9) 1.92 (0.63 – 5.84) 0.252
CEA at baseline Normal 7/21 65.0 (44.0 – 86.0) 2.29 (0.90 – 5.82) 0.082
  Abnormal 12/17 37.5 (13.8 – 61.2) -  
Hemoglobin Normal 7/14 44.5 (16.5 – 72.5) -  
  Abnormal 15/24 43.5 (23.3 – 63.7) 1.27 (0.52 – 3.31) 0.604
Albumin Normal 12/22 46.7 (24.9 – 68.5) -  
  Abnormal 10/16 40.0 (15.3 – 64.7) 1.14 (0.49 – 2.65) 0.756
LDH Normal 7/13 48.0 (18.6 – 77.4) -  
  Abnormal 7/12 50.0 (21.8 – 78.2) 0.87 (0.30 – 2.52) 0.874
Alk.Ph Normal 14/24 43.1 (22.5 – 63.7) -  
  Abnormal 8/14 46.2 (19.2 – 73.2) 0.75 (0.31 – 1.79) 0.512
ALT Normal 16/29 46.0 (27.4 – 64.6) -  
  Abnormal 5/8 42.9 (6.2 – 79.6) 1.05 (0.38 – 2.89) 0.921
Platelets Normal 21/43 50.9 (35.0 – 66.8) -  
  Abnormal 1/2 0 6.68 (0.77 – 57.6) 0.084