Figure 3

Gene testing showed the proband (arrow) and one son were heterozygous for the TP53 germline mutation [E+ (mut/wt)]. Her two daughters were homozygous for the wild-type TP53 gene (E-). ‘E’ represents test information on the pedigree. The arrow indicates the proband. The asterisk indicates the kindred who had been examined for the TP53 gene mutation. Abbreviations: dx., diagnosis as; Emca, endometrial cancer; PMM, peritoneal malignant mesothelioma; y, years old. The pedigree was generated according to the recommendations for Pedigree Standardization Task Force of the National Society of Genetic Counselors.