Table 2 Correlation between expression of nuclear factor (erythroid-2)–related factor 2 (Nrf2) and clinicopathological factors
Clinical factors | Expression of Nrf2 | P- value | |
|---|---|---|---|
Negative | Positive | ||
n = 67 (38.3%) | n = 108 (61.7%) | ||
Age | n.s. | ||
  < 65 | 22 | 47 | |
 ≧65 | 45 | 61 | |
Gender | <0.05 | ||
 male | 51 | 65 | |
 female | 16 | 43 | |
Tumor size | <0.01 | ||
  < 5 cm | 36 | 27 | |
 ≧5 cm | 31 | 81 | |
Tumor depth | <0.01 | ||
 T1a, T1b, T2 | 31 | 19 | |
 T3, T4a, T4b | 36 | 89 | |
Lymph node metastases | <0.05 | ||
 Yes | 35 | 74 | |
 No | 32 | 34 | |
Stage | <0.01 | ||
 IA, IB | 28 | 19 | |
 IIA, IIB | 12 | 21 | |
 IIIA, IIIB, IIIC | 27 | 68 | |
Lymphovascular invasion | <0.05 | ||
 Yes | 49 | 90 | |
 No | 18 | 14 | |
Histology | <0.01 | ||
 Differentiated | 37 | 34 | |
 Undifferentiated | 30 | 74 | |