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Table 1 A summary of the unique genetic events associated with the chemotherapy curable malignancies

From: Clinical observations on chemotherapy curable malignancies: unique genetic events, frozen development and enduring apoptotic potential

Tumour type Unique genetic event Modern cure rate for metastatic disease Standard drugs Reference
Trophoblast tumours  
Post Mole GTT Nuclear Fusion 100% Methotrexate or Dactinomycin [29]
Gestational choriocarcinoma Nuclear Fusion 95% Etoposide, Methotrexate Dactinomycin, Cyclophosphamide, Vincristine [30]
PSTT Nuclear Fusion 49% Etoposide, Methotrexate Dactinomycin, Etoposide, Cisplatin [31]
Germ cell tumours  
Testicular cancer Meiosis 90% Bleomycin, Etoposide, Cisplatin [32]
Ovarian germ cell tumour Meiosis 81% Bleomycin, Etoposide, Cisplatin [33]
Childhood malignancies  
Wilms Gastrulation 80% Dactinomycin, Vincristine, Doxorubicin [34]
Neuroblastoma Gastrulation 40–90% Carboplatin, Etoposide, Cyclophosphamide, Doxorubicin [35]
Ewings Gastrulation 30% Vincristine, Doxorubicin, Ifosfamide, Etoposide Busulphan Melphalan [36]
Acute leukemia  
B ALL VDJ rearrangement Child 85% Dexamethasone, Vincristine, Asparaginase Daunorubicin [37,38]
Adult 53%
T ALL VDJ rearrangement Child 75% Dexamethasone, Vincristine, Asparaginase Daunorubicin [39]
AML VDJ rearrangement 40% Daunorubicin, Cytarabine [40]
B Cell malignancies  
Hodgkin’s lymphoma Somatic Hypermutation 80% Doxorubicin, Bleomycin Vinblastine Dacarbazine [41]
Diffuse large B cell lymphoma Somatic Hypermutation 75% (GCB) Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, Rituximab [42]
40% (ABC)
Burkitt’s lymphoma Somatic Hypermutation 80% Cyclophosphamide, Vincristine, Doxorubicin, Methotrexate, Ifosfamide [43]
Etoposide, Cytarabine
T Cell malignancies  
ALK + ve anaplastic large cell lymphoma V(D)J rearrangement 80% Cyclophosphamide, Doxorubicin, Vincristine, Prednisone [44]