Figure 2
Comparison of free and liposome encapsulated CLO and ZOL potencies. A Effect of BPs on the growth inhibition and cytotoxicity of J774 cells after 48 h of treatment. IC50 and EC50 values represent the 95% confidence intervals of the normalised, non-linear fitted values. B IPP, ApppI and AppCCl2p accumulation in J774 cells after BP treatment. ND, levels below the limit of detection. ***p < 0.0001, one-way ANOVA with Dunnett’s multiple comparison test as compared with the CTR. C Western blot analysis of the effect of ZOL, ZOL-LIP and EMP-LIP treatment on protein prenylation and other key mevalonate pathway molecules. The results are representative of three independent experiments.