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Figure 5 | BMC Cancer

Figure 5

From: The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells

Figure 5

HNHA induced cytochrome c-dependent, caspase-dependent apoptotic death in RCCs. Subcellular fractionation showed that the Bax level was increased, and cytochrome c release into the cytosol was enhanced by HNHA, in Caki-1 (A) and A 498 cells (B). Immunofluorescent cytochemical staining showed that cytochrome c was translocated and accumulated in the nucleus, suggesting that HNHA induced apoptosis through a cytochrome-c-dependent pathway. (C, D) Western blot analysis after subcellular fractionation confirmed that cytochrome c was translocated into the nucleus after HNHA treatment (E, F).

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