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Figure 3 | BMC Cancer

Figure 3

From: The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells

Figure 3

HNHA induced G0/G1 phase arrest and apoptosis in RCC cells. FACS flow cytometry with propidium iodide staining showed that HNHA induced G0/G1 phase arrest and increased the sub-G0 population in Caki-1 and A-498 cells (A). Western blotting showed that HNHA potently induced the expression of cell cycle arrest proteins (p53 and p21), reduced positive regulators of cell cycle progression (CDK4/6 and cyclin D1) and resulted in increased levels of anti-apoptotic (Bax and Apaf-1) proteins in RCC cells (B).

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