Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins

Table 4 velocity P values

Sample	2D	3D	Wt 10 nM	Wt 50 nM	mAb13	mAb13 +Wt 10 nM	mAb13 Wt 50 nM
untreated
Ctrl	< 0.0001***	-	0.0023**	< 0.0001***	< 0.0001***	< 0.0001***	< 0.0001***
TA	< 0.0001***	0.1606	0.5286	0.0003***	< 0.0001***	< 0.0001***	< 0.0001***
Wt 10 nM
Ctrl	-	-	-	0.2859	< 0.0001***	0.0190*	0.0193*
TA	-	-	-	0.0114*	< 0.0001***	< 0.0001***	< 0.0001***
Wt 50 nM
Ctrl	-	-	-	-	0.0002***	0.1075	0.1571
TA	-	-	-	-	0.0304*	0.0247*	0.0002***
mAb13
Ctrl	-	-	-	-	-	0.0348*	0.0015**
TA	-	-	-	-	-	0.8733	0.1978
mAb13 + Wt 10 nM
Ctrl	-	-	-	-	-	-	0.4986
TA	-	-	-	-	-	-	0.2165

P values were obtained using Mann-Whitney test. Non-significant values are underlined while relative significance levels are designated as extremely***, very**, or significant*. Bolded data represent conditions in which differences were observed between control and tumor-associated 3D matrix induced velocity due to stated treatments.

ISSN: 1471-2407