Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins

Table 2 morphology P values

Sample	2D	3D	Wt 10 nM	Wt 50 nM	mAb13	mAb13 +Wt 10 nM	mAb13 Wt 50 nM
untreated
Ctrl	< 0.0001***	-	0.0016**	< 0.0001***	< 0.0001***	< 0.0001***	< 0.0001***
TA	< 0.0001***	< 0.0001***	0.5975	< 0.0001***	< 0.0001***	< 0.0001***	< 0.0001***
Wt 10 nM
Ctrl	-	-	-	0.1902	0.0221**	0.0009***	< 0.0001***
TA	-	-	-	< 0.0001***	< 0.0001***	< 0.0001***	< 0.0001***
Wt 50 nM
Ctrl	-	-	-	-	0.2022	0.0042**	< 0.0001***
TA	-	-	-	-	0.0005***	< 0.0001***	< 0.0001***
mAb13
Ctrl	-	-	-	-	-	0.1687	0.0005***
TA	-	-	-	-	-	0.4596	0.0108*
mAb13 + Wt 10 nM
Ctrl	-	-	-	-	-	-	0.0686
TA	-	-	-	-	-	-	0.0742

P values were obtained using Mann-Whitney test. Non-significant values are underlined while relative significance levels are designated as extremely***, very**, or significant*. Bolded data represent conditions in which differences were observed between control and tumor-associated 3D matrix induced EFF due to stated treatments.

ISSN: 1471-2407