Table 1 Comparison of clinicopathological features with HER-2 status using CISH, qRT-PCR (qPCR), and IHC.
Variables (n)a | CISH | P * | qPCR | P * | IHC | P * | |||
|---|---|---|---|---|---|---|---|---|---|
≤ 5 | >10 | ≤ 2.00 | >2.00 | 0/1+ | 2/3+ | ||||
Age (years) | |||||||||
≤ 50 (28) | 9 | 5 | 0.9541 | 15 | 13 | 0.2569 | 17 | 11 | 0.3651 |
>50 (48) | 15 | 8 | 32 | 16 | 34 | 14 | |||
Lymph node status | |||||||||
<4 (57) | 21 | 9 | 0.1756 | 38 | 19 | 0.0915 | 40 | 17 | 0.4723 |
≥ 4 (32) | 3 | 4 | 8 | 10 | 11 | 7 | |||
ND (1) | 0 | 0 | 0 | 1 | 0 | 1 | |||
Tumor Size (cm) | |||||||||
0 – 2 (19) | 5 | 5 | 0.1883 | 10 | 9 | 0.2953 | 11 | 8 | 0.2745 |
>2 (56) | 19 | 7 | 37 | 19 | 40 | 16 | |||
ND (1) | 0 | 1 | 0 | 1 | 0 | 1 | |||
Clinical Stage | |||||||||
I/IIA/IIB (65) | 21 | 9 | 0.1756 | 41 | 24 | 0.5901 | 44 | 21 | 0.7912 |
IIIA/IIIB (11) | 3 | 4 | 6 | 5 | 7 | 4 | |||
Histologic grade | |||||||||
I/II (36) | 10 | 6 | 1.000 | 22 | 14 | 0.9237 | 23 | 13 | 0.6767 |
III (35) | 10 | 6 | 21 | 14 | 24 | 11 | |||
ND (5) | 4 | 1 | 4 | 1 | 4 | 1 | |||
Ki-67 status | |||||||||
Low (≤ 25%) (32) | 11 | 6 | 0.5133 | 19 | 13 | 0.5354 | 21 | 11 | 0.7209 |
High (> 25%) (31) | 8 | 7 | 16 | 15 | 19 | 12 | |||
Not reactive (13) | 5 | 0 | 12 | 1 | 11 | 2 | |||
Familial History of Cancer | |||||||||
Yes (15) | 4 | 3 | 0.6346 | 7 | 8 | 0.1769 | 10 | 5 | 0.9678 |
No (61) | 20 | 10 | 40 | 21 | 41 | 20 | |||