Figure 5
From: Characterization of STAT3 activation and expression in canine and human osteosarcoma
Inhibition of Src or STAT3 leads to loss of OSA cell proliferation and apoptosis via the caspase 3,7 pathway. A) Canine or B) human OSA cell lines were treated with DMSO, SU6656, or LLL3 for 1, 3, or 5 days. Proliferation was analyzed using the CyQUANT cell proliferation assay kit. Apoptosis was assessed by measuring active caspase-3/7 using the SensoLyte® Homogeneous AMC Caspase-3/7 Assay kit. Proliferation values are listed as a percentage of DMSO control. *p < 0.05