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Table 3 Association between CPA4 variants and advanced prostate cancer, stratified by age at diagnosis (using 66 years as cutpoint)

From: Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer

   Age < 66 years Age ≥ 66 years
SNP Genotype Cases Controls Odds Ratio
(95% CI)*
p-value Controls Cases Odds Ratio
(95% CI)*
p-value
rs901799 CC 178 (74.8) 173 (72.7) 1   199 (74.3) 185 (69.0) 1  
  CA 56 (23.5) 61
(25.6)
0.89 (0.59–1.36) 0.60 60
(22.4)
75 (28.0) 1.35 (0.91–2.00) 0.14
  AA 4
(1.7)
4
(1.7)
0.98 (0.24–4.00) 0.98 9
(3.4)
8
(3.2)
0.96 (0.36–2.54) 0.93
rs3807344 AA 109 (45.8) 90
(37.8)
1   111 (41.4) 104 (38.8) 1  
  AG 98 (41.2) 120 (50.4) 0.67 (0.46–0.99) 0.05 124 (46.3) 123 (45.9) 1.06 (0.73–1.53) 0.76
  GG 31 (13.0) 28
(11.8)
0.91 (0.51–1.64) 0.76 33
(12.3)
41 (15.3) 1.33 (0.78–2.26) 0.30
rs1569132 AA 85 (35.7) 82
(34.5)
1   83
(31.0)
87 (32.5) 1  
  AG 98 (41.2) 121 (50.8) 0.78 (0.52–1.17) 0.23 131 (48.9) 136 (50.8) 0.99 (0.67–1.46) 0.96
  GG 55 (23.1) 35
(14.7)
1.51 (0.90–2.55) 0.12 54
(20.2)
45 (16.8) 0.80 (0.48–1.31) 0.37
rs1038628 GG 106 (44.5) 107 (45.0) 1   105 (39.2) 103 (38.4) 1  
  GT 91 (38.2) 102 (42.9) 0.91 (0.61–1.35) 0.62 119 (44.4) 129 (48.1) 1.11 (0.76–1.61) 0.60
  TT 41 (17.2) 29
(12.2)
1.44 (0.82–2.53) 0.20 44
(16.4)
36 (13.4) 0.83 (0.49–1.41) 0.50
rs2171492 GG 107 (45.0) 108 (45.4) 1   104 (38.8) 109 (40.7) 1  
  GT 90 (37.8) 107 (45.0) 0.86 (0.58–1.27) 0.44 126 (47.0) 126 (47.0) 0.95 (0.66–1.38) 0.79
  TT 41 (17.2) 23
(9.7)
1.83 (1.02–3.36) 0.04 38
(14.2)
33 (12.3) 0.83 (0.48–1.42) 0.49
rs1488009 AA 186 (78.2) 190 (79.8) 1   197 (73.5) 216 (80.6) 1  
  AG 49 (20.6) 46
(19.3)
1.09 (0.69–1.72) 0.71 68
(25.4)
44 (16.4) 0.58 (0.38–0.90) 0.01
  GG 3
(1.3)
2
(0.8)
1.53 (0.25–9.31) 0.65 3
(1.1)
8
(3.0)
2.47 (0.64–9.46) 0.19
  1. * From unconditional logistic regression model adjusted for age, ethnicity, and medical institution.