Table 3 Association between CPA4 variants and advanced prostate cancer, stratified by age at diagnosis (using 66 years as cutpoint)
From: Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer
Age < 66 years | Age ≥ 66 years | ||||||||
|---|---|---|---|---|---|---|---|---|---|
SNP | Genotype | Cases | Controls | Odds Ratio (95% CI)* | p-value | Controls | Cases | Odds Ratio (95% CI)* | p-value |
rs901799 | CC | 178 (74.8) | 173 (72.7) | 1 | 199 (74.3) | 185 (69.0) | 1 | ||
CA | 56 (23.5) | 61 (25.6) | 0.89 (0.59–1.36) | 0.60 | 60 (22.4) | 75 (28.0) | 1.35 (0.91–2.00) | 0.14 | |
AA | 4 (1.7) | 4 (1.7) | 0.98 (0.24–4.00) | 0.98 | 9 (3.4) | 8 (3.2) | 0.96 (0.36–2.54) | 0.93 | |
rs3807344 | AA | 109 (45.8) | 90 (37.8) | 1 | 111 (41.4) | 104 (38.8) | 1 | ||
AG | 98 (41.2) | 120 (50.4) | 0.67 (0.46–0.99) | 0.05 | 124 (46.3) | 123 (45.9) | 1.06 (0.73–1.53) | 0.76 | |
GG | 31 (13.0) | 28 (11.8) | 0.91 (0.51–1.64) | 0.76 | 33 (12.3) | 41 (15.3) | 1.33 (0.78–2.26) | 0.30 | |
rs1569132 | AA | 85 (35.7) | 82 (34.5) | 1 | 83 (31.0) | 87 (32.5) | 1 | ||
AG | 98 (41.2) | 121 (50.8) | 0.78 (0.52–1.17) | 0.23 | 131 (48.9) | 136 (50.8) | 0.99 (0.67–1.46) | 0.96 | |
GG | 55 (23.1) | 35 (14.7) | 1.51 (0.90–2.55) | 0.12 | 54 (20.2) | 45 (16.8) | 0.80 (0.48–1.31) | 0.37 | |
rs1038628 | GG | 106 (44.5) | 107 (45.0) | 1 | 105 (39.2) | 103 (38.4) | 1 | ||
GT | 91 (38.2) | 102 (42.9) | 0.91 (0.61–1.35) | 0.62 | 119 (44.4) | 129 (48.1) | 1.11 (0.76–1.61) | 0.60 | |
TT | 41 (17.2) | 29 (12.2) | 1.44 (0.82–2.53) | 0.20 | 44 (16.4) | 36 (13.4) | 0.83 (0.49–1.41) | 0.50 | |
rs2171492 | GG | 107 (45.0) | 108 (45.4) | 1 | 104 (38.8) | 109 (40.7) | 1 | ||
GT | 90 (37.8) | 107 (45.0) | 0.86 (0.58–1.27) | 0.44 | 126 (47.0) | 126 (47.0) | 0.95 (0.66–1.38) | 0.79 | |
TT | 41 (17.2) | 23 (9.7) | 1.83 (1.02–3.36) | 0.04 | 38 (14.2) | 33 (12.3) | 0.83 (0.48–1.42) | 0.49 | |
rs1488009 | AA | 186 (78.2) | 190 (79.8) | 1 | 197 (73.5) | 216 (80.6) | 1 | ||
AG | 49 (20.6) | 46 (19.3) | 1.09 (0.69–1.72) | 0.71 | 68 (25.4) | 44 (16.4) | 0.58 (0.38–0.90) | 0.01 | |
GG | 3 (1.3) | 2 (0.8) | 1.53 (0.25–9.31) | 0.65 | 3 (1.1) | 8 (3.0) | 2.47 (0.64–9.46) | 0.19 | |