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Table 4 Pharmacokinetic analysis- Population estimates for the therapeutic dose of I131 KAb201.

From: Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I131KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma

Parameter

 

Intra-arterial group

Intravenous group

Volume of distribution

mean (SE)

0.0032 (0.0004) L

0.0031 (0.0003) L

Elimination rate

mean (SE)

0.0944 (0.0095) litres/hour

0.1498 (0.0176) litres/hour

Area under Curve

mean (range)

15801.0 (5673.4, 30011.2) ng/ml

12411.3 (4748.3, 20713.8) ng/ml

Cmax

mean (range)

1488.7 (644.5, 2328.5) ng/ml

1812.7 (1002.8, 2600.3) ng/ml

  1. SE = standard error; L = litre; h = hour; ng = nanogram; ml= millilitres
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BMC Cancer

ISSN: 1471-2407

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