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Table 4 Pharmacokinetic analysis- Population estimates for the therapeutic dose of I131 KAb201.

From: Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I131KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma

Parameter   Intra-arterial group Intravenous group
Volume of distribution mean (SE) 0.0032 (0.0004) L 0.0031 (0.0003) L
Elimination rate mean (SE) 0.0944 (0.0095) litres/hour 0.1498 (0.0176) litres/hour
Area under Curve mean (range) 15801.0 (5673.4, 30011.2) ng/ml 12411.3 (4748.3, 20713.8) ng/ml
Cmax mean (range) 1488.7 (644.5, 2328.5) ng/ml 1812.7 (1002.8, 2600.3) ng/ml
  1. SE = standard error; L = litre; h = hour; ng = nanogram; ml= millilitres